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1437: Small Monomer Design

Closed since over 8 years ago

Intermediate Overall Design

Summary

Created
October 06, 2017
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 65-75 residues. We've softened the penalties associated with the Core Existence filter, which have typically been very steep. The starting structure has 65 residues, but more can be added at a cost of 16 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

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    1. Anthropic Dreams
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  10. Avatar for Biochem-AD17 10. Biochem-AD17 6 pts. 9,082
  1. Avatar for multaq 141. multaq Lv 1 1 pt. 0
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  3. Avatar for PBanks2017 143. PBanks2017 Lv 1 1 pt. 0
  4. Avatar for jmey 144. jmey Lv 1 1 pt. 0
  5. Avatar for Sigrid1402 145. Sigrid1402 Lv 1 1 pt. 0
  6. Avatar for biochem123 146. biochem123 Lv 1 1 pt. 0
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Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets; penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 65. Players may use up to 75 residues in total.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."