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1449: Large Monomer Design

Closed since over 8 years ago

Intermediate Overall Design

Summary

Created
November 13, 2017
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 85-105 residues. We've softened the penalties associated with the Core Existence filter, which have typically been very steep. The starting structure has 85 residues, but more can be added at a cost of 16 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

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    1. Beta Folders
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  2. Avatar for LavenderSky 112. LavenderSky Lv 1 1 pt. 6,993
  3. Avatar for xabxs 113. xabxs Lv 1 1 pt. 6,381
  4. Avatar for Hebrew Hitman 114. Hebrew Hitman Lv 1 1 pt. 6,222
  5. Avatar for Deleted player 115. Deleted player pts. 5,995
  6. Avatar for ikalvet 116. ikalvet Lv 1 1 pt. 5,772
  7. Avatar for ViJay7019 117. ViJay7019 Lv 1 1 pt. 5,471
  8. Avatar for Jim Fraser 118. Jim Fraser Lv 1 1 pt. 5,287
  9. Avatar for lamoille 119. lamoille Lv 1 1 pt. 5,284
  10. Avatar for DrDoomDoom 120. DrDoomDoom Lv 1 1 pt. 5,224

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 35% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets; penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 85. Players may use up to 105 residues in total.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."