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1458: Small Monomer Design

Closed since about 8 years ago

Intermediate Overall Design

Summary

Created
December 11, 2017
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 65-75 residues. We've softened the penalties associated with the Core Existence filter, which have typically been very steep. The starting structure has 65 residues, but more can be added at a cost of 16 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Beta Folders
    1. Beta Folders
    100 pts. 10,212
  2. Avatar for Gargleblasters 2. Gargleblasters 76 pts. 10,204
  3. Avatar for Go Science 3. Go Science 56 pts. 10,195
  4. Avatar for Anthropic Dreams 4. Anthropic Dreams 41 pts. 10,149
  5. Avatar for Void Crushers 5. Void Crushers 29 pts. 10,071
  6. Avatar for Contenders 6. Contenders 20 pts. 10,062
  7. Avatar for Marvin's bunch 7. Marvin's bunch 14 pts. 9,994
  8. Avatar for L'Alliance Francophone 8. L'Alliance Francophone 9 pts. 9,884
  9. Avatar for GENE 433 9. GENE 433 6 pts. 9,266
  10. Avatar for Russian team 10. Russian team 4 pts. 9,240
  1. Avatar for jallinvi 151. jallinvi Lv 1 1 pt. 0
  2. Avatar for Idiotboy 152. Idiotboy Lv 1 1 pt. 0
  3. Avatar for AzukayIRC 153. AzukayIRC Lv 1 1 pt. 0
  4. Avatar for eromana 154. eromana Lv 1 1 pt. 0
  5. Avatar for jeff101 155. jeff101 Lv 1 1 pt. 0
  6. Avatar for Cyberkashi 156. Cyberkashi Lv 1 1 pt. 0
  7. Avatar for RAH 157. RAH Lv 1 1 pt. 0
  8. Avatar for tokens 158. tokens Lv 1 1 pt. 0
  9. Avatar for hada 159. hada Lv 1 1 pt. 0
  10. Avatar for dettingen 160. dettingen Lv 1 1 pt. 0

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets; penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 65. Players may use up to 75 residues in total.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."