Placeholder image of a protein
Icon representing a puzzle

1460: Large Monomer Design

Closed since about 8 years ago

Intermediate Overall Design

Summary

Created
December 19, 2017
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 85-105 residues. We've softened the penalties associated with the Core Existence filter, which have typically been very steep. The starting structure has 85 residues, but more can be added at a cost of 16 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Gargleblasters
    1. Gargleblasters
    100 pts. 10,822
  2. Avatar for Beta Folders 2. Beta Folders 74 pts. 10,808
  3. Avatar for Go Science 3. Go Science 54 pts. 10,746
  4. Avatar for Anthropic Dreams 4. Anthropic Dreams 38 pts. 10,722
  5. Avatar for Contenders 5. Contenders 27 pts. 10,574
  6. Avatar for Void Crushers 6. Void Crushers 18 pts. 10,551
  7. Avatar for L'Alliance Francophone 7. L'Alliance Francophone 12 pts. 10,233
  8. Avatar for Marvin's bunch 8. Marvin's bunch 8 pts. 10,086
  9. Avatar for GENE 433 9. GENE 433 5 pts. 9,918
  10. Avatar for Deleted group 10. Deleted group pts. 9,547
  1. Avatar for yoyoparis 71. yoyoparis Lv 1 6 pts. 8,860
  2. Avatar for froggs554 72. froggs554 Lv 1 6 pts. 8,777
  3. Avatar for mitarcher 73. mitarcher Lv 1 6 pts. 8,759
  4. Avatar for G Man 74. G Man Lv 1 6 pts. 8,671
  5. Avatar for Vincera 75. Vincera Lv 1 5 pts. 8,655
  6. Avatar for rinze 76. rinze Lv 1 5 pts. 8,647
  7. Avatar for flemdogmillionaire 77. flemdogmillionaire Lv 1 5 pts. 8,644
  8. Avatar for davidgn 78. davidgn Lv 1 4 pts. 8,632
  9. Avatar for doctaven 79. doctaven Lv 1 4 pts. 8,626
  10. Avatar for cobaltteal 80. cobaltteal Lv 1 4 pts. 8,625

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 35% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets; penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 85. Players may use up to 105 residues in total.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."

actiasluna Lv 1

Was this puzzle's expiration date extended due to the chat issues? This morning it is giving me 7 days 10 hours when I swear yesterday it said 4.

bkoep Staff Lv 1

Hmm, that's strange. We haven't changed the expiration date since the puzzle was posted.