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1464: Medium Monomer Design

Closed since about 8 years ago

Intermediate Overall Design

Summary

Created
December 26, 2017
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 75-90 residues. We've softened the penalties associated with the Core Existence filter, which have typically been very steep. The starting structure has 75 residues, but more can be added at a cost of 16 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Gargleblasters
    1. Gargleblasters
    100 pts. 10,511
  2. Avatar for Beta Folders 2. Beta Folders 63 pts. 10,479
  3. Avatar for Anthropic Dreams 3. Anthropic Dreams 37 pts. 10,475
  4. Avatar for Go Science 4. Go Science 21 pts. 10,442
  5. Avatar for Void Crushers 5. Void Crushers 11 pts. 10,298
  6. Avatar for Contenders 6. Contenders 5 pts. 10,288
  7. Avatar for L'Alliance Francophone 7. L'Alliance Francophone 2 pts. 10,257
  8. Avatar for Deleted group 8. Deleted group pts. 9,490
  9. Avatar for GENE 433 9. GENE 433 1 pt. 9,314
  10. Avatar for Marvin's bunch 10. Marvin's bunch 1 pt. 8,942
  1. Avatar for Anfinsen_slept_here 11. Anfinsen_slept_here Lv 1 63 pts. 10,321
  2. Avatar for ZeroLeak7 12. ZeroLeak7 Lv 1 60 pts. 10,303
  3. Avatar for Timo van der Laan 13. Timo van der Laan Lv 1 58 pts. 10,298
  4. Avatar for Bletchley Park 14. Bletchley Park Lv 1 55 pts. 10,288
  5. Avatar for phi16 15. phi16 Lv 1 52 pts. 10,267
  6. Avatar for crpainter 16. crpainter Lv 1 50 pts. 10,258
  7. Avatar for Museka 17. Museka Lv 1 47 pts. 10,257
  8. Avatar for Skippysk8s 18. Skippysk8s Lv 1 45 pts. 10,246
  9. Avatar for Glen B 19. Glen B Lv 1 42 pts. 10,241
  10. Avatar for Deleted player 20. Deleted player pts. 10,228

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets; penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 75. Players may use up to 90 residues in total.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues in your solution count as "loops."