1467: Extra Large Monomer Design

Closed since about 8 years ago

Summary

• Created: January 05, 2018
• Expires: January 12, 2018 at 23:00 UTC
• Max points: 100

Description

This puzzle challenges players to design a protein with 95-120 residues. We've softened the penalties associated with the Core Existence and Residue Count filters, which have typically been very steep. The starting structure has 95 residues, but more can be added at a cost of 16 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

• 11. freefolder 1 pt. 7,069
• 12. Trinity Biology 1 pt. 6,497
• 13. Deleted group pts. 2,164
• 14. DSN @ Home 1 pt. 0

Top evolvers

• 1. toshiue 100 pts. 11,030
• 2. Hollinas 76 pts. 11,029
• 3. Bruno Kestemont 56 pts. 11,020
• 4. NinjaGreg 41 pts. 11,016
• 5. Anfinsen_slept_here 29 pts. 11,012
• 6. ZeroLeak7 20 pts. 11,009
• 7. isaksson 14 pts. 11,007
• 8. LociOiling 9 pts. 10,992
• 9. Skippysk8s 6 pts. 10,980
• 10. retiredmichael 4 pts. 10,952

Comments

[bkoep]

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 35% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets; penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 95. Players may use up to 120 residues in total.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."