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1467: Extra Large Monomer Design

Closed since about 8 years ago

Intermediate Overall Design

Summary

Created
January 05, 2018
Expires
Max points
100
Description

This puzzle challenges players to design a protein with 95-120 residues. We've softened the penalties associated with the Core Existence and Residue Count filters, which have typically been very steep. The starting structure has 95 residues, but more can be added at a cost of 16 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Go Science
    1. Go Science
    100 pts. 11,033
  2. Avatar for Gargleblasters 2. Gargleblasters 68 pts. 11,001
  3. Avatar for Beta Folders 3. Beta Folders 44 pts. 10,995
  4. Avatar for Contenders 4. Contenders 27 pts. 10,786
  5. Avatar for L'Alliance Francophone 5. L'Alliance Francophone 16 pts. 10,691
  6. Avatar for Anthropic Dreams 6. Anthropic Dreams 9 pts. 10,664
  7. Avatar for Void Crushers 7. Void Crushers 5 pts. 10,613
  8. Avatar for Deleted group 8. Deleted group pts. 9,542
  9. Avatar for GENE 433 9. GENE 433 1 pt. 9,491
  10. Avatar for Marvin's bunch 10. Marvin's bunch 1 pt. 7,127
  1. Avatar for gulsahsimsir 81. gulsahsimsir Lv 1 1 pt. 7,267
  2. Avatar for Jumbly 82. Jumbly Lv 1 1 pt. 7,147
  3. Avatar for NotJim99 83. NotJim99 Lv 1 1 pt. 7,127
  4. Avatar for cjreinholt 84. cjreinholt Lv 1 1 pt. 7,121
  5. Avatar for dbuske 85. dbuske Lv 1 1 pt. 7,098
  6. Avatar for Altercomp 86. Altercomp Lv 1 1 pt. 7,069
  7. Avatar for 01010011111 87. 01010011111 Lv 1 1 pt. 6,535
  8. Avatar for alyssa_d 88. alyssa_d Lv 1 1 pt. 6,497
  9. Avatar for Deleted player 89. Deleted player pts. 5,447
  10. Avatar for Pibeagles 90. Pibeagles Lv 1 1 pt. 4,426

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 35% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets; penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 95. Players may use up to 120 residues in total.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."