Placeholder image of a protein
Icon representing a puzzle

1470: Small Monomer Design

Closed since about 8 years ago

Intermediate Overall Design

Summary

Created
January 12, 2018
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 65-75 residues. In this design puzzle, we've deactivated the Ideal Loops filter, so players have more flexibility to design their own high-scoring loops! The starting structure has 65 residues, but more can be added at a cost of 16 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Eὕρηκα! Heureka! 11. Eὕρηκα! Heureka! 1 pt. 8,369
  2. Avatar for Trinity Biology 12. Trinity Biology 1 pt. 8,144
  3. Avatar for Rechenkraft.net 13. Rechenkraft.net 1 pt. 8,072
  4. Avatar for Deleted group 14. Deleted group pts. 3,819
  5. Avatar for BCC 15. BCC 1 pt. 0
  6. Avatar for DSN @ Home 16. DSN @ Home 1 pt. 0
  1. Avatar for fishercat 51. fishercat Lv 1 9 pts. 9,306
  2. Avatar for momadoc 52. momadoc Lv 1 8 pts. 9,305
  3. Avatar for Amphimixus 53. Amphimixus Lv 1 8 pts. 9,292
  4. Avatar for benrh 54. benrh Lv 1 7 pts. 9,267
  5. Avatar for rabamino12358 55. rabamino12358 Lv 1 7 pts. 9,198
  6. Avatar for alwen 56. alwen Lv 1 6 pts. 9,186
  7. Avatar for bzipitidoo 57. bzipitidoo Lv 1 6 pts. 9,180
  8. Avatar for multaq 58. multaq Lv 1 6 pts. 9,165
  9. Avatar for WBarme1234 59. WBarme1234 Lv 1 5 pts. 9,158
  10. Avatar for pfirth 60. pfirth Lv 1 5 pts. 9,142

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets; penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 65. Players may use up to 75 residues in total.