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1470: Small Monomer Design

Closed since about 8 years ago

Intermediate Overall Design

Summary

Created
January 12, 2018
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 65-75 residues. In this design puzzle, we've deactivated the Ideal Loops filter, so players have more flexibility to design their own high-scoring loops! The starting structure has 65 residues, but more can be added at a cost of 16 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Gargleblasters
    1. Gargleblasters
    100 pts. 10,172
  2. Avatar for Beta Folders 2. Beta Folders 71 pts. 10,166
  3. Avatar for Go Science 3. Go Science 49 pts. 10,153
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  6. Avatar for Void Crushers 6. Void Crushers 14 pts. 10,078
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  8. Avatar for L'Alliance Francophone 8. L'Alliance Francophone 5 pts. 9,563
  9. Avatar for GENE 433 9. GENE 433 3 pts. 9,552
  10. Avatar for Deleted group 10. Deleted group pts. 9,533
  1. Avatar for Sissue 41. Sissue Lv 1 16 pts. 9,533
  2. Avatar for Knoblerine 42. Knoblerine Lv 1 15 pts. 9,502
  3. Avatar for SaraL 43. SaraL Lv 1 14 pts. 9,494
  4. Avatar for Flagg65a 44. Flagg65a Lv 1 13 pts. 9,455
  5. Avatar for Deleted player 45. Deleted player pts. 9,440
  6. Avatar for keithv 46. keithv Lv 1 12 pts. 9,434
  7. Avatar for Bautho 47. Bautho Lv 1 11 pts. 9,418
  8. Avatar for MicElephant 48. MicElephant Lv 1 10 pts. 9,344
  9. Avatar for micheldeweerd 49. micheldeweerd Lv 1 10 pts. 9,341
  10. Avatar for abiogenesis 50. abiogenesis Lv 1 9 pts. 9,306

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets; penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 65. Players may use up to 75 residues in total.