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1473: Primitive 80 Residue Monomer Design

Closed since about 8 years ago

Intermediate Overall Design

Summary

Created
January 19, 2018
Expires
Max points
100
Description

This is an unusual puzzle, in that we've disabled all of the special tools and filters normally used for Foldit protein design. Foldit has changed a great deal since we ran the first Foldit design puzzle, back in August of 2009, and the results of recent design puzzles have shown that Foldit players are now perfectly capable of designing well-folded, stable proteins. We'd like to write up a paper about these results, and it will be important to have a clear picture of what happens without those special tools and filters now used for protein design. For this puzzle only, we're asking Foldit players to forget everything you've learned about protein design! This puzzle uses only a basic Rosetta scoring function, and we do not expect top-scoring designs to be realistic. But we're very curious whether Foldit players will find the same solutions as back in 2009. What is the best-scoring structure you can come up with, without the filters and design tools?

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Comments

Susume Lv 1

Foldit's mutate function is not operating normally on this puzzle. On my sheet-and-helix solution, after several manual runs of mutate all at various CI levels, and after a long script that mutates smaller areas, my sheets are still almost completely hydrophobic, inside and out. I have tried setting all the outside residues on the sheets to GLU (which should stay in at least some of the spots because of its high reference score), and foldit quickly puts hydrophobics back into those spots. Foldit design puzzles normally have zero "exposed" residues - this one has eight.

Shared solution with scientists, called "1473 Why is my sheet all orange".