1499b: Symmetric Dimer Design: Hydrogen Bond Networks

Closed since almost 8 years ago

Summary

• Created: March 21, 2018
• Expires: March 27, 2018 at 23:00 UTC
• Max points: 100

Description

Note: This puzzle replaces Puzzle 1499 which was posted with a problematic filter. Players may load in solutions from Puzzle 1499.



This symmetric design puzzle has C2 symmetry, with two symmetric chains. The H-bond Network Filter encourages players to bury satisfied H-bond networks at the interface between the two chains. There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

• 1. Go Science 100 pts. 795
• 2. Beta Folders 1 pt. 0

Top soloists

• 1. rabamino12358 100 pts. 1,805
• 2. NinjaGreg 14 pts. 795
• 3. johnmitch 1 pt. 0
• 4. smilingone 1 pt. 0

Comments

[bkoep]

Core Existence: Monomer: Ensures that at least 25% residues are buried in the core of the monomer unit.

Core Existence: Complex: Ensures that at least 30% residues are buried in the core of the entire complex (including the interface between monomer units).

HBond Network: Rewards networks comprising at least three hydrogen bonds. Up to four hydrogen bonds may span the interface between chains. Networks must at least 50% satisfied (i.e. 50% of all polar atoms in a network must make a hydrogen bond).