Placeholder image of a protein
Icon representing a puzzle

1504: Large Monomer Design

Closed since almost 8 years ago

Intermediate Overall Design

Summary

Created
April 03, 2018
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 85-105 residues. The starting structure has 85 residues, but more can be added at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Gargleblasters
    1. Gargleblasters
    100 pts. 11,942
  2. Avatar for Beta Folders 2. Beta Folders 63 pts. 11,916
  3. Avatar for Anthropic Dreams 3. Anthropic Dreams 37 pts. 11,798
  4. Avatar for Go Science 4. Go Science 21 pts. 11,625
  5. Avatar for Void Crushers 5. Void Crushers 11 pts. 11,531
  6. Avatar for L'Alliance Francophone 6. L'Alliance Francophone 5 pts. 11,262
  7. Avatar for FoldIt@Netherlands 7. FoldIt@Netherlands 2 pts. 11,103
  8. Avatar for Marvin's bunch 8. Marvin's bunch 1 pt. 10,942
  9. Avatar for Contenders 9. Contenders 1 pt. 10,867
  10. Avatar for Trinity Biology 10. Trinity Biology 1 pt. 9,231
  1. Avatar for phi16 11. phi16 Lv 1 1 pt. 11,740
  2. Avatar for Deleted player 12. Deleted player pts. 11,736
  3. Avatar for alcor29 13. alcor29 Lv 1 1 pt. 11,731
  4. Avatar for toshiue 14. toshiue Lv 1 1 pt. 11,625
  5. Avatar for Bruno Kestemont 15. Bruno Kestemont Lv 1 1 pt. 11,598
  6. Avatar for sciencewalker 16. sciencewalker Lv 1 1 pt. 11,557
  7. Avatar for alwen 17. alwen Lv 1 1 pt. 10,980

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 85, at a cost of 32 points per residue. Players may use up to 105 residues in total.