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1509: Small Monomer Design

Closed since almost 8 years ago

Intermediate Overall Design

Summary

Created
April 17, 2018
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 65-75 residues. The starting structure has 65 residues, but more can be added at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

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    1. Beta Folders
    100 pts. 10,966
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  9. Avatar for Trinity Biology 9. Trinity Biology 1 pt. 8,887
  10. Avatar for Team China 10. Team China 1 pt. 7,293
  1. Avatar for toshiue 41. toshiue Lv 1 9 pts. 10,070
  2. Avatar for rezaefar 42. rezaefar Lv 1 8 pts. 10,024
  3. Avatar for lconor 43. lconor Lv 1 8 pts. 9,982
  4. Avatar for momadoc 44. momadoc Lv 1 7 pts. 9,973
  5. Avatar for silent gene 45. silent gene Lv 1 7 pts. 9,966
  6. Avatar for christioanchauvin 46. christioanchauvin Lv 1 6 pts. 9,949
  7. Avatar for Deleted player 47. Deleted player pts. 9,942
  8. Avatar for weitzen 48. weitzen Lv 1 5 pts. 9,901
  9. Avatar for parsnip 49. parsnip Lv 1 5 pts. 9,870
  10. Avatar for rabamino12358 50. rabamino12358 Lv 1 4 pts. 9,786

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 65, at a cost of 32 points per residue. Players may use up to 75 residues in total.