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1513: Extra Large Monomer Design

Closed since almost 8 years ago

Intermediate Overall Design

Summary

Created
April 24, 2018
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 95-120 residues. The starting structure has 95 residues, but more can be added at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for DSN @ Home 11. DSN @ Home 1 pt. 1,633
  2. Avatar for Team China 12. Team China 1 pt. 0
  3. Avatar for Window Group 13. Window Group 1 pt. 0
  1. Avatar for isaksson
    1. isaksson Lv 1
    100 pts. 12,533
  2. Avatar for Galaxie 2. Galaxie Lv 1 96 pts. 12,415
  3. Avatar for actiasluna 3. actiasluna Lv 1 91 pts. 12,400
  4. Avatar for Enzyme 4. Enzyme Lv 1 87 pts. 12,329
  5. Avatar for dcrwheeler 5. dcrwheeler Lv 1 83 pts. 12,318
  6. Avatar for Deleted player 6. Deleted player pts. 12,284
  7. Avatar for LociOiling 7. LociOiling Lv 1 75 pts. 12,281
  8. Avatar for Glen B 8. Glen B Lv 1 71 pts. 12,207
  9. Avatar for johnmitch 9. johnmitch Lv 1 67 pts. 12,204
  10. Avatar for Blipperman 10. Blipperman Lv 1 64 pts. 12,167

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 95, at a cost of 32 points per residue. Players may use up to 120 residues in total.