Placeholder image of a protein
Icon representing a puzzle

1513: Extra Large Monomer Design

Closed since almost 8 years ago

Intermediate Overall Design

Summary

Created
April 24, 2018
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 95-120 residues. The starting structure has 95 residues, but more can be added at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Go Science
    1. Go Science
    100 pts. 12,533
  2. Avatar for Anthropic Dreams 2. Anthropic Dreams 65 pts. 12,419
  3. Avatar for Gargleblasters 3. Gargleblasters 41 pts. 12,408
  4. Avatar for Beta Folders 4. Beta Folders 24 pts. 12,281
  5. Avatar for L'Alliance Francophone 5. L'Alliance Francophone 14 pts. 11,742
  6. Avatar for Void Crushers 6. Void Crushers 7 pts. 11,685
  7. Avatar for Marvin's bunch 7. Marvin's bunch 4 pts. 11,207
  8. Avatar for Deleted group 8. Deleted group pts. 11,071
  9. Avatar for Trinity Biology 9. Trinity Biology 1 pt. 9,018
  10. Avatar for foldeRNA 10. foldeRNA 1 pt. 7,440
  1. Avatar for robgee 21. robgee Lv 1 34 pts. 11,681
  2. Avatar for christioanchauvin 22. christioanchauvin Lv 1 32 pts. 11,591
  3. Avatar for Anfinsen_slept_here 23. Anfinsen_slept_here Lv 1 31 pts. 11,589
  4. Avatar for Timo van der Laan 24. Timo van der Laan Lv 1 29 pts. 11,574
  5. Avatar for Vinara 25. Vinara Lv 1 27 pts. 11,524
  6. Avatar for jamiexq 26. jamiexq Lv 1 25 pts. 11,518
  7. Avatar for NinjaGreg 27. NinjaGreg Lv 1 24 pts. 11,509
  8. Avatar for Bautho 28. Bautho Lv 1 22 pts. 11,424
  9. Avatar for WBarme1234 29. WBarme1234 Lv 1 21 pts. 11,403
  10. Avatar for retiredmichael 30. retiredmichael Lv 1 20 pts. 11,395

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 95, at a cost of 32 points per residue. Players may use up to 120 residues in total.