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1513: Extra Large Monomer Design

Closed since almost 8 years ago

Intermediate Overall Design

Summary

Created
April 24, 2018
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 95-120 residues. The starting structure has 95 residues, but more can be added at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

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    1. Go Science
    100 pts. 12,533
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  1. Avatar for 01010011111 81. 01010011111 Lv 1 1 pt. 3,584
  2. Avatar for Waterscott Finn 82. Waterscott Finn Lv 1 1 pt. 3,167
  3. Avatar for andrewxc 83. andrewxc Lv 1 1 pt. 2,163
  4. Avatar for CMmartinez 84. CMmartinez Lv 1 1 pt. 1,659
  5. Avatar for aspadistra 85. aspadistra Lv 1 1 pt. 1,633
  6. Avatar for Dranon 86. Dranon Lv 1 1 pt. 1,547
  7. Avatar for NotJim99 87. NotJim99 Lv 1 1 pt. 1,284
  8. Avatar for fatelt 88. fatelt Lv 1 1 pt. 0
  9. Avatar for Arne Heessels 89. Arne Heessels Lv 1 1 pt. 0
  10. Avatar for Deleted player 90. Deleted player pts. 0

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 95, at a cost of 32 points per residue. Players may use up to 120 residues in total.