Placeholder image of a protein
Icon representing a puzzle

1521: Symmetric Dimer Design: Hydrogen Bond Networks

Closed since almost 8 years ago

Intermediate Overall Design Symmetry

Summary

Created
May 15, 2018
Expires
Max points
100
Description

This symmetric design puzzle has C2 symmetry, with two symmetric chains. The H-bond Network Filter encourages players to bury satisfied H-bond networks at the interface between the two chains. There a couple other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Trinity Biology 11. Trinity Biology 1 pt. 4,673
  2. Avatar for Deleted group 12. Deleted group pts. 0
  3. Avatar for freefolder 13. freefolder 1 pt. 0
  4. Avatar for Androids 14. Androids 1 pt. 0
  5. Avatar for :) 15. :) 1 pt. 0
  1. Avatar for jamiexq 51. jamiexq Lv 1 8 pts. 14,388
  2. Avatar for diamonddays 52. diamonddays Lv 1 8 pts. 14,385
  3. Avatar for erikviking 53. erikviking Lv 1 7 pts. 14,351
  4. Avatar for DoctorSockrates 54. DoctorSockrates Lv 1 7 pts. 14,251
  5. Avatar for ManVsYard 55. ManVsYard Lv 1 6 pts. 14,217
  6. Avatar for YeshuaLives 56. YeshuaLives Lv 1 6 pts. 14,073
  7. Avatar for silent gene 57. silent gene Lv 1 5 pts. 14,055
  8. Avatar for cbwest 58. cbwest Lv 1 5 pts. 13,768
  9. Avatar for Neil9 59. Neil9 Lv 1 5 pts. 13,270
  10. Avatar for Psych0Active 60. Psych0Active Lv 1 4 pts. 13,254

Comments

bkoep Staff Lv 1

Core Existence: Monomer: Ensures that at least 22 residues are buried in the core of the monomer unit.

Core Existence: Complex: Ensures that at least 50 residues are buried in the core of the entire complex (including the interface between monomer units).

HBond Network: Rewards networks comprising at least three hydrogen bonds. Up to four hydrogen bonds may span the interface between chains. Networks must at least 50% satisfied (i.e. 50% of all polar atoms in a network must make a hydrogen bond).