Placeholder image of a protein
Icon representing a puzzle

1521: Symmetric Dimer Design: Hydrogen Bond Networks

Closed since almost 8 years ago

Intermediate Overall Design Symmetry

Summary

Created
May 15, 2018
Expires
Max points
100
Description

This symmetric design puzzle has C2 symmetry, with two symmetric chains. The H-bond Network Filter encourages players to bury satisfied H-bond networks at the interface between the two chains. There a couple other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Go Science
    1. Go Science
    100 pts. 17,103
  2. Avatar for Beta Folders 2. Beta Folders 70 pts. 17,100
  3. Avatar for Void Crushers 3. Void Crushers 47 pts. 17,016
  4. Avatar for Gargleblasters 4. Gargleblasters 30 pts. 16,801
  5. Avatar for Marvin's bunch 5. Marvin's bunch 19 pts. 16,723
  6. Avatar for Anthropic Dreams 6. Anthropic Dreams 11 pts. 16,682
  7. Avatar for Contenders 7. Contenders 7 pts. 16,468
  8. Avatar for L'Alliance Francophone 8. L'Alliance Francophone 4 pts. 15,693
  9. Avatar for HMT heritage 9. HMT heritage 2 pts. 15,277
  10. Avatar for Deleted group 10. Deleted group pts. 14,579
  1. Avatar for pvc78 11. pvc78 Lv 1 66 pts. 16,626
  2. Avatar for Deleted player 12. Deleted player pts. 16,620
  3. Avatar for Bruno Kestemont 13. Bruno Kestemont Lv 1 61 pts. 16,602
  4. Avatar for Galaxie 14. Galaxie Lv 1 58 pts. 16,583
  5. Avatar for bertro 15. bertro Lv 1 55 pts. 16,575
  6. Avatar for phi16 16. phi16 Lv 1 53 pts. 16,530
  7. Avatar for Skippysk8s 17. Skippysk8s Lv 1 51 pts. 16,526
  8. Avatar for dcrwheeler 18. dcrwheeler Lv 1 48 pts. 16,489
  9. Avatar for crpainter 19. crpainter Lv 1 46 pts. 16,468
  10. Avatar for Bletchley Park 20. Bletchley Park Lv 1 44 pts. 16,444

Comments

bkoep Staff Lv 1

Core Existence: Monomer: Ensures that at least 22 residues are buried in the core of the monomer unit.

Core Existence: Complex: Ensures that at least 50 residues are buried in the core of the entire complex (including the interface between monomer units).

HBond Network: Rewards networks comprising at least three hydrogen bonds. Up to four hydrogen bonds may span the interface between chains. Networks must at least 50% satisfied (i.e. 50% of all polar atoms in a network must make a hydrogen bond).