Placeholder image of a protein
Icon representing a puzzle

1530: Symmetric Trimer Design: Hydrogen Bond Networks

Closed since almost 8 years ago

Intermediate Overall Design Symmetry

Summary

Created
June 05, 2018
Expires
Max points
100
Description

This symmetric design puzzle has C3 symmetry, with three symmetric chains. The H-bond Network Filter encourages players to bury satisfied H-bond networks at the interface between the three chains. We've doubled the H-bond network bonus, but we'd like players to focus on building networks deep in the core of the protein complex. There a couple other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Trinity Biology 11. Trinity Biology 1 pt. 7,047
  2. Avatar for Richard Dawkins Foundation 12. Richard Dawkins Foundation 1 pt. 3,937
  3. Avatar for test_group1 13. test_group1 1 pt. 335
  4. Avatar for DSN @ Home 14. DSN @ Home 1 pt. 0
  1. Avatar for mirjamvandelft 91. mirjamvandelft Lv 1 1 pt. 2,754
  2. Avatar for Vincera 92. Vincera Lv 1 1 pt. 2,671
  3. Avatar for larry25427 93. larry25427 Lv 1 1 pt. 699
  4. Avatar for test_account1 94. test_account1 Lv 1 1 pt. 335
  5. Avatar for Keresto 95. Keresto Lv 1 1 pt. 0
  6. Avatar for dam_01 96. dam_01 Lv 1 1 pt. 0
  7. Avatar for aspadistra 97. aspadistra Lv 1 1 pt. 0
  8. Avatar for navn 98. navn Lv 1 1 pt. 0
  9. Avatar for may of rose 99. may of rose Lv 1 1 pt. 0
  10. Avatar for materixas 100. materixas Lv 1 1 pt. 0

Comments

bkoep Staff Lv 1

Core Existence: Monomer: Ensures that at least 21 residues are buried in the core of the monomer unit.

Core Existence: Complex: Ensures that at least 63 residues are buried in the core of the entire complex (including the interface between monomer units). The threshold of "buriedness" between core and surface residues is more stringent than usual, so residues may have to be "extra buried" to be counted toward the core of the protein complex.

HBond Network: Rewards networks that comprise at least three hydrogen bonds involving core residues. Networks must be at least 75% satisfied (i.e. 75% of all polar atoms in a network must make a hydrogen bond).