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1536: Small Monomer Design

Closed since over 7 years ago

Intermediate Overall Design

Summary

Created
June 19, 2018
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 65-75 residues. The starting structure has 65 residues, but more can be added at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for freefolder 11. freefolder 2 pts. 10,047
  2. Avatar for Team Schleswig-Holstein 12. Team Schleswig-Holstein 1 pt. 9,827
  3. Avatar for Deleted group 13. Deleted group pts. 9,051
  4. Avatar for Team South Africa 14. Team South Africa 1 pt. 8,931
  5. Avatar for DSN @ Home 15. DSN @ Home 1 pt. 8,378
  6. Avatar for Trinity Biology 16. Trinity Biology 1 pt. 8,270
  7. Avatar for Richard Dawkins Foundation 17. Richard Dawkins Foundation 1 pt. 8,261
  8. Avatar for Window Group 18. Window Group 1 pt. 0
  1. Avatar for LociOiling
    1. LociOiling Lv 1
    100 pts. 10,865
  2. Avatar for Bruno Kestemont 2. Bruno Kestemont Lv 1 96 pts. 10,785
  3. Avatar for actiasluna 3. actiasluna Lv 1 92 pts. 10,782
  4. Avatar for frood66 4. frood66 Lv 1 88 pts. 10,767
  5. Avatar for johnmitch 5. johnmitch Lv 1 85 pts. 10,762
  6. Avatar for Galaxie 6. Galaxie Lv 1 81 pts. 10,755
  7. Avatar for Deleted player 7. Deleted player pts. 10,747
  8. Avatar for Susume 8. Susume Lv 1 74 pts. 10,744
  9. Avatar for gdnskye 9. gdnskye Lv 1 71 pts. 10,722
  10. Avatar for pvc78 10. pvc78 Lv 1 68 pts. 10,692

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 65, at a cost of 32 points per residue. Players may use up to 75 residues in total.