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1543: Medium Monomer Design

Closed since over 7 years ago

Intermediate Overall Design

Summary

Created
July 03, 2018
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 75-90 residues. The starting structure has 75 residues, but more can be added at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Team South Africa 11. Team South Africa 1 pt. 9,098
  2. Avatar for Trinity Biology 12. Trinity Biology 1 pt. 7,958
  3. Avatar for Team Schleswig-Holstein 13. Team Schleswig-Holstein 1 pt. 0
  1. Avatar for fiendish_ghoul 11. fiendish_ghoul Lv 1 61 pts. 11,198
  2. Avatar for frood66 12. frood66 Lv 1 58 pts. 11,165
  3. Avatar for johnmitch 13. johnmitch Lv 1 55 pts. 11,144
  4. Avatar for crpainter 14. crpainter Lv 1 52 pts. 11,114
  5. Avatar for toshiue 15. toshiue Lv 1 50 pts. 11,087
  6. Avatar for NinjaGreg 16. NinjaGreg Lv 1 47 pts. 11,083
  7. Avatar for dcrwheeler 17. dcrwheeler Lv 1 45 pts. 11,081
  8. Avatar for Bautho 18. Bautho Lv 1 42 pts. 11,044
  9. Avatar for mirp 19. mirp Lv 1 40 pts. 11,022
  10. Avatar for Blipperman 20. Blipperman Lv 1 38 pts. 11,007

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 75, at a cost of 32 points per residue. Players may use up to 90 residues in total.