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1543: Medium Monomer Design

Closed since over 7 years ago

Intermediate Overall Design

Summary

Created
July 03, 2018
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 75-90 residues. The starting structure has 75 residues, but more can be added at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Anthropic Dreams
    1. Anthropic Dreams
    100 pts. 11,415
  2. Avatar for Beta Folders 2. Beta Folders 65 pts. 11,379
  3. Avatar for Gargleblasters 3. Gargleblasters 41 pts. 11,368
  4. Avatar for Marvin's bunch 4. Marvin's bunch 24 pts. 11,302
  5. Avatar for Go Science 5. Go Science 14 pts. 11,285
  6. Avatar for Void Crushers 6. Void Crushers 7 pts. 11,220
  7. Avatar for Contenders 7. Contenders 4 pts. 11,114
  8. Avatar for HMT heritage 8. HMT heritage 2 pts. 10,583
  9. Avatar for L'Alliance Francophone 9. L'Alliance Francophone 1 pt. 10,426
  10. Avatar for FoldIt@Netherlands 10. FoldIt@Netherlands 1 pt. 10,424
  1. Avatar for gdnskye 101. gdnskye Lv 1 1 pt. 0
  2. Avatar for Petrifolder 102. Petrifolder Lv 1 1 pt. 0
  3. Avatar for cbwest 103. cbwest Lv 1 1 pt. 0
  4. Avatar for devjosh 104. devjosh Lv 1 1 pt. 0
  5. Avatar for Knoblerine 105. Knoblerine Lv 1 1 pt. 0
  6. Avatar for alcor29 106. alcor29 Lv 1 1 pt. 0
  7. Avatar for antibot215 107. antibot215 Lv 1 1 pt. 0

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 75, at a cost of 32 points per residue. Players may use up to 90 residues in total.