Placeholder image of a protein
Icon representing a puzzle

1552: Find the Hydrogen Bond Networks!

Closed since over 7 years ago

Intermediate Overall Prediction

Summary

Created
July 21, 2018
Expires
Max points
100
Description

This puzzle is a little different from other prediction puzzles in Foldit. This protein is a dimer (i.e. two chains fold up and bind each other) that was designed in the Baker Lab. The design has two identical H-bond networks that span the interface between the two chains. In order to solve this puzzle, Foldit players will have to fold each of the two chains, bring them together, and arrange the interface to form the two H-bond networks. The secondary structure of the designed protein is marked on the starting structure. See if you can fold this protein and find the H-bond networks!

Top groups

  1. Avatar for Go Science
    1. Go Science
    100 pts. 14,768
  2. Avatar for Anthropic Dreams 2. Anthropic Dreams 63 pts. 14,162
  3. Avatar for Gargleblasters 3. Gargleblasters 37 pts. 14,088
  4. Avatar for Beta Folders 4. Beta Folders 21 pts. 13,814
  5. Avatar for HMT heritage 5. HMT heritage 11 pts. 13,712
  6. Avatar for L'Alliance Francophone 6. L'Alliance Francophone 5 pts. 13,281
  7. Avatar for Contenders 7. Contenders 2 pts. 13,274
  8. Avatar for Marvin's bunch 8. Marvin's bunch 1 pt. 13,273
  9. Avatar for Void Crushers 9. Void Crushers 1 pt. 13,042
  10. Avatar for Stuyvesant Molecular Science 2017-18 10. Stuyvesant Molecular Science 2017-18 1 pt. 11,815
  1. Avatar for tyler0911 21. tyler0911 Lv 1 38 pts. 13,136
  2. Avatar for nicobul 22. nicobul Lv 1 36 pts. 13,129
  3. Avatar for dcrwheeler 23. dcrwheeler Lv 1 34 pts. 13,114
  4. Avatar for fiendish_ghoul 24. fiendish_ghoul Lv 1 32 pts. 13,110
  5. Avatar for Galaxie 25. Galaxie Lv 1 30 pts. 13,104
  6. Avatar for Timo van der Laan 26. Timo van der Laan Lv 1 28 pts. 13,042
  7. Avatar for Crossed Sticks 27. Crossed Sticks Lv 1 27 pts. 12,982
  8. Avatar for LociOiling 28. LociOiling Lv 1 25 pts. 12,979
  9. Avatar for robgee 29. robgee Lv 1 24 pts. 12,943
  10. Avatar for spvincent 30. spvincent Lv 1 23 pts. 12,943

Comments

bkoep Staff Lv 1

Core Existence: Complex: Ensures that at least 48 residues are buried in the core of the entire complex (including the interface between monomer units).

HBond Network: Rewards networks that comprise at least three hydrogen bonds involving core residues. Networks must be at least 75% satisfied (i.e. 75% of all polar atoms in a network must make a hydrogen bond).