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1552: Find the Hydrogen Bond Networks!

Closed since over 7 years ago

Intermediate Overall Prediction

Summary

Created
July 21, 2018
Expires
Max points
100
Description

This puzzle is a little different from other prediction puzzles in Foldit. This protein is a dimer (i.e. two chains fold up and bind each other) that was designed in the Baker Lab. The design has two identical H-bond networks that span the interface between the two chains. In order to solve this puzzle, Foldit players will have to fold each of the two chains, bring them together, and arrange the interface to form the two H-bond networks. The secondary structure of the designed protein is marked on the starting structure. See if you can fold this protein and find the H-bond networks!

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Comments

bkoep Staff Lv 1

Core Existence: Complex: Ensures that at least 48 residues are buried in the core of the entire complex (including the interface between monomer units).

HBond Network: Rewards networks that comprise at least three hydrogen bonds involving core residues. Networks must be at least 75% satisfied (i.e. 75% of all polar atoms in a network must make a hydrogen bond).