Placeholder image of a protein
Icon representing a puzzle

1557: Extra Small Monomer Design

Closed since over 7 years ago

Intermediate Overall Design

Summary

Created
August 02, 2018
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 60-65 residues. The starting structure has 60 residues, but more can be inserted at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for foldeRNA 11. foldeRNA 1 pt. 8,642
  2. Avatar for Window Group 12. Window Group 1 pt. 0
  1. Avatar for larry25427 91. larry25427 Lv 1 1 pt. 8,166
  2. Avatar for alyssajoyh 92. alyssajoyh Lv 1 1 pt. 8,040
  3. Avatar for sboy171772 93. sboy171772 Lv 1 1 pt. 7,636
  4. Avatar for anthion 94. anthion Lv 1 1 pt. 7,344
  5. Avatar for tpham16 95. tpham16 Lv 1 1 pt. 7,099
  6. Avatar for JellyJump 96. JellyJump Lv 1 1 pt. 6,518
  7. Avatar for lamoille 97. lamoille Lv 1 1 pt. 6,321
  8. Avatar for sasailab 98. sasailab Lv 1 1 pt. 5,665
  9. Avatar for Ethrandir 99. Ethrandir Lv 1 1 pt. 5,577
  10. Avatar for Eron333 100. Eron333 Lv 1 1 pt. 5,101

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 60, at a cost of 32 points per residue. Players may use up to 65 residues in total.