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1557: Extra Small Monomer Design

Closed since over 7 years ago

Intermediate Overall Design

Summary

Created
August 02, 2018
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 60-65 residues. The starting structure has 60 residues, but more can be inserted at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for foldeRNA 11. foldeRNA 1 pt. 8,642
  2. Avatar for Window Group 12. Window Group 1 pt. 0
  1. Avatar for toshiue 41. toshiue Lv 1 13 pts. 10,139
  2. Avatar for silent gene 42. silent gene Lv 1 12 pts. 10,123
  3. Avatar for YeshuaLives 43. YeshuaLives Lv 1 11 pts. 10,115
  4. Avatar for WBarme1234 44. WBarme1234 Lv 1 11 pts. 10,114
  5. Avatar for NinjaGreg 45. NinjaGreg Lv 1 10 pts. 10,114
  6. Avatar for rezaefar 46. rezaefar Lv 1 9 pts. 10,058
  7. Avatar for sciencewalker 47. sciencewalker Lv 1 9 pts. 10,054
  8. Avatar for jeff101 48. jeff101 Lv 1 8 pts. 10,024
  9. Avatar for Museka 49. Museka Lv 1 8 pts. 10,010
  10. Avatar for ViJay7019 50. ViJay7019 Lv 1 7 pts. 10,003

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 60, at a cost of 32 points per residue. Players may use up to 65 residues in total.