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1557: Extra Small Monomer Design

Closed since over 7 years ago

Intermediate Overall Design

Summary

Created
August 02, 2018
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 60-65 residues. The starting structure has 60 residues, but more can be inserted at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for foldeRNA 11. foldeRNA 1 pt. 8,642
  2. Avatar for Window Group 12. Window Group 1 pt. 0
  1. Avatar for YGK 71. YGK Lv 1 2 pts. 9,552
  2. Avatar for SouperGenious 72. SouperGenious Lv 1 1 pt. 9,467
  3. Avatar for plasterosporanny 73. plasterosporanny Lv 1 1 pt. 9,448
  4. Avatar for LadyFEN 74. LadyFEN Lv 1 1 pt. 9,336
  5. Avatar for Vincera 75. Vincera Lv 1 1 pt. 9,334
  6. Avatar for mitarcher 76. mitarcher Lv 1 1 pt. 9,292
  7. Avatar for pfirth 77. pfirth Lv 1 1 pt. 9,275
  8. Avatar for jobo0502 78. jobo0502 Lv 1 1 pt. 9,219
  9. Avatar for navn 79. navn Lv 1 1 pt. 9,153
  10. Avatar for TastyMunchies 80. TastyMunchies Lv 1 1 pt. 9,150

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 60, at a cost of 32 points per residue. Players may use up to 65 residues in total.