Placeholder image of a protein
Icon representing a puzzle

1557: Extra Small Monomer Design

Closed since over 7 years ago

Intermediate Overall Design

Summary

Created
August 02, 2018
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 60-65 residues. The starting structure has 60 residues, but more can be inserted at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Beta Folders
    1. Beta Folders
    100 pts. 10,684
  2. Avatar for Go Science 2. Go Science 63 pts. 10,665
  3. Avatar for Gargleblasters 3. Gargleblasters 37 pts. 10,619
  4. Avatar for Anthropic Dreams 4. Anthropic Dreams 21 pts. 10,600
  5. Avatar for Contenders 5. Contenders 11 pts. 10,565
  6. Avatar for Void Crushers 6. Void Crushers 5 pts. 10,493
  7. Avatar for Marvin's bunch 7. Marvin's bunch 2 pts. 10,353
  8. Avatar for HMT heritage 8. HMT heritage 1 pt. 10,238
  9. Avatar for L'Alliance Francophone 9. L'Alliance Francophone 1 pt. 10,010
  10. Avatar for freefolder 10. freefolder 1 pt. 8,794
  1. Avatar for alwen 61. alwen Lv 1 3 pts. 9,897
  2. Avatar for JMStiffler 62. JMStiffler Lv 1 3 pts. 9,847
  3. Avatar for Flagg65a 63. Flagg65a Lv 1 3 pts. 9,847
  4. Avatar for Rastamasta 64. Rastamasta Lv 1 3 pts. 9,827
  5. Avatar for diamonddays 65. diamonddays Lv 1 2 pts. 9,812
  6. Avatar for momadoc 66. momadoc Lv 1 2 pts. 9,771
  7. Avatar for rabamino12358 67. rabamino12358 Lv 1 2 pts. 9,765
  8. Avatar for Deleted player 68. Deleted player pts. 9,735
  9. Avatar for DoctorSockrates 69. DoctorSockrates Lv 1 2 pts. 9,672
  10. Avatar for parsnip 70. parsnip Lv 1 2 pts. 9,611

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 60, at a cost of 32 points per residue. Players may use up to 65 residues in total.