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1561: Symmetric Dimer Design: Hydrogen Bond Networks

Closed since over 7 years ago

Advanced Overall Design Symmetry

Summary


Created
August 13, 2018
Expires
Max points
100
Description

This symmetric design puzzle has C2 symmetry, with two symmetric chains. The H-bond Network Bonus encourages players to bury satisfied H-bond networks at the interface between the two chains. We've doubled the H-bond network bonus, but we'd like players to focus on building networks deep in the core of the protein complex. There are a couple other bonuses in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups


  1. Avatar for freefolder 12. freefolder 1 pt. 8,572
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  3. Avatar for Rechenkraft.net 15. Rechenkraft.net 1 pt. 0
  4. Avatar for test_group1 16. test_group1 1 pt. 0

  1. Avatar for frood66 21. frood66 Lv 1 45 pts. 15,196
  2. Avatar for pvc78 22. pvc78 Lv 1 43 pts. 15,173
  3. Avatar for MurloW 23. MurloW Lv 1 41 pts. 15,137
  4. Avatar for Crossed Sticks 24. Crossed Sticks Lv 1 39 pts. 15,058
  5. Avatar for matosfran 25. matosfran Lv 1 37 pts. 14,997
  6. Avatar for stomjoh 26. stomjoh Lv 1 36 pts. 14,995
  7. Avatar for cbwest 27. cbwest Lv 1 34 pts. 14,975
  8. Avatar for Vinara 28. Vinara Lv 1 33 pts. 14,853
  9. Avatar for Bautho 29. Bautho Lv 1 31 pts. 14,825
  10. Avatar for YeshuaLives 30. YeshuaLives Lv 1 30 pts. 14,788

Comments


bkoep Staff Lv 1

Core Existence: Monomer: Ensures that at least 21 residues are buried in the core of the monomer unit.

Core Existence: Complex: Ensures that at least 42 residues are buried in the core of the entire complex (including the interface between monomer units). The threshold of "buriedness" between core and surface residues is more stringent than usual, so residues may have to be "extra buried" to be counted toward the core of the protein complex.

HBond Network: Rewards networks that comprise at least three hydrogen bonds involving core residues. Networks must be at least 75% satisfied (i.e. 75% of all polar atoms in a network must make a hydrogen bond).