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1574: Extra Small Monomer Design

Closed since over 7 years ago

Intermediate Overall Design

Summary

Created
September 13, 2018
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 60-65 residues. The starting structure has 60 residues, but more can be inserted at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Russian team 11. Russian team 1 pt. 10,971
  2. Avatar for freefolder 12. freefolder 1 pt. 10,221
  3. Avatar for BCC 13. BCC 1 pt. 0
  4. Avatar for Firebirds BioChem 14. Firebirds BioChem 1 pt. 0
  1. Avatar for pvc78 11. pvc78 Lv 1 65 pts. 11,902
  2. Avatar for Anfinsen_slept_here 12. Anfinsen_slept_here Lv 1 63 pts. 11,894
  3. Avatar for crpainter 13. crpainter Lv 1 60 pts. 11,876
  4. Avatar for reefyrob 14. reefyrob Lv 1 57 pts. 11,846
  5. Avatar for fiendish_ghoul 15. fiendish_ghoul Lv 1 55 pts. 11,800
  6. Avatar for Timo van der Laan 16. Timo van der Laan Lv 1 52 pts. 11,768
  7. Avatar for frood66 17. frood66 Lv 1 50 pts. 11,763
  8. Avatar for Mark- 18. Mark- Lv 1 47 pts. 11,758
  9. Avatar for Skippysk8s 19. Skippysk8s Lv 1 45 pts. 11,754
  10. Avatar for hpaege 20. hpaege Lv 1 43 pts. 11,753

Comments

bkoep Staff Lv 1

Residue IE Score (max +500)
Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Residue Count (max +160)
Penalizes extra residues inserted beyond the starting 60, at a cost of 32 points per residue. Players may use up to 65 residues in total.

Secondary Structure (max +500)
No more than 10% of residues may form helices. Extra helices are penalized at 10 points per residue.