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1574: Extra Small Monomer Design

Closed since over 7 years ago

Intermediate Overall Design

Summary

Created
September 13, 2018
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 60-65 residues. The starting structure has 60 residues, but more can be inserted at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Russian team 11. Russian team 1 pt. 10,971
  2. Avatar for freefolder 12. freefolder 1 pt. 10,221
  3. Avatar for BCC 13. BCC 1 pt. 0
  4. Avatar for Firebirds BioChem 14. Firebirds BioChem 1 pt. 0
  1. Avatar for Vincera 81. Vincera Lv 1 1 pt. 10,500
  2. Avatar for antibot215 82. antibot215 Lv 1 1 pt. 10,453
  3. Avatar for Knoblerine 83. Knoblerine Lv 1 1 pt. 10,448
  4. Avatar for ReallyRatherDumb 84. ReallyRatherDumb Lv 1 1 pt. 10,440
  5. Avatar for Arne Heessels 85. Arne Heessels Lv 1 1 pt. 10,386
  6. Avatar for azvolpe 86. azvolpe Lv 1 1 pt. 10,269
  7. Avatar for Altercomp 87. Altercomp Lv 1 1 pt. 10,221
  8. Avatar for orily1337 88. orily1337 Lv 1 1 pt. 10,189
  9. Avatar for atlas100 89. atlas100 Lv 1 1 pt. 9,564
  10. Avatar for Jesse Pinkman 90. Jesse Pinkman Lv 1 1 pt. 9,553

Comments

bkoep Staff Lv 1

Residue IE Score (max +500)
Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Residue Count (max +160)
Penalizes extra residues inserted beyond the starting 60, at a cost of 32 points per residue. Players may use up to 65 residues in total.

Secondary Structure (max +500)
No more than 10% of residues may form helices. Extra helices are penalized at 10 points per residue.