Placeholder image of a protein
Icon representing a puzzle

1574: Extra Small Monomer Design

Closed since over 7 years ago

Intermediate Overall Design

Summary

Created
September 13, 2018
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 60-65 residues. The starting structure has 60 residues, but more can be inserted at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Gargleblasters
    1. Gargleblasters
    100 pts. 12,027
  2. Avatar for Beta Folders 2. Beta Folders 68 pts. 12,013
  3. Avatar for Go Science 3. Go Science 44 pts. 12,005
  4. Avatar for Anthropic Dreams 4. Anthropic Dreams 27 pts. 11,999
  5. Avatar for Contenders 5. Contenders 16 pts. 11,876
  6. Avatar for Marvin's bunch 6. Marvin's bunch 9 pts. 11,775
  7. Avatar for Void Crushers 7. Void Crushers 5 pts. 11,768
  8. Avatar for HMT heritage 8. HMT heritage 3 pts. 11,191
  9. Avatar for L'Alliance Francophone 9. L'Alliance Francophone 1 pt. 11,160
  10. Avatar for FoldIt@Netherlands 10. FoldIt@Netherlands 1 pt. 11,031
  1. Avatar for guineapig 51. guineapig Lv 1 7 pts. 11,134
  2. Avatar for momadoc 52. momadoc Lv 1 7 pts. 11,119
  3. Avatar for wisky 53. wisky Lv 1 7 pts. 11,106
  4. Avatar for Merf 54. Merf Lv 1 6 pts. 11,098
  5. Avatar for MicElephant 55. MicElephant Lv 1 6 pts. 11,087
  6. Avatar for KimJongUn 56. KimJongUn Lv 1 5 pts. 11,087
  7. Avatar for ourtown 57. ourtown Lv 1 5 pts. 11,068
  8. Avatar for sciencewalker 58. sciencewalker Lv 1 5 pts. 11,060
  9. Avatar for JasperD 59. JasperD Lv 1 4 pts. 11,031
  10. Avatar for jausmh 60. jausmh Lv 1 4 pts. 11,018

Comments

bkoep Staff Lv 1

Residue IE Score (max +500)
Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Residue Count (max +160)
Penalizes extra residues inserted beyond the starting 60, at a cost of 32 points per residue. Players may use up to 65 residues in total.

Secondary Structure (max +500)
No more than 10% of residues may form helices. Extra helices are penalized at 10 points per residue.