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1578: Medium Monomer Design

Closed since over 7 years ago

Intermediate Overall Design

Summary

Created
September 28, 2018
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 75-90 residues. The starting structure has 75 residues, but more can be added at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for freefolder 11. freefolder 1 pt. 10,374
  2. Avatar for FoldIt@Netherlands 12. FoldIt@Netherlands 1 pt. 5,922
  1. Avatar for Galaxie
    1. Galaxie Lv 1
    100 pts. 13,158
  2. Avatar for johnmitch 2. johnmitch Lv 1 95 pts. 13,098
  3. Avatar for actiasluna 3. actiasluna Lv 1 90 pts. 13,003
  4. Avatar for spvincent 4. spvincent Lv 1 85 pts. 12,964
  5. Avatar for MurloW 5. MurloW Lv 1 81 pts. 12,960
  6. Avatar for reefyrob 6. reefyrob Lv 1 76 pts. 12,940
  7. Avatar for retiredmichael 7. retiredmichael Lv 1 72 pts. 12,930
  8. Avatar for phi16 8. phi16 Lv 1 68 pts. 12,916
  9. Avatar for fiendish_ghoul 9. fiendish_ghoul Lv 1 64 pts. 12,877
  10. Avatar for crpainter 10. crpainter Lv 1 61 pts. 12,874

Comments

bkoep Staff Lv 1

Residue IE Score (max +500)
Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA, SER, THR in helices.

Residue Count (max +480)
Penalizes extra residues inserted beyond the starting 75, at a cost of 32 points per residue. Players may use up to 90 residues in total.

Secondary Structure (max +500)
No more than 10% of residues may form helices. Extra helices are penalized at 10 points per residue.