1581: Small Monomer Design

Closed since over 7 years ago

Summary

• Created: October 03, 2018
• Expires: October 11, 2018 at 23:00 UTC
• Max points: 100

Description

This puzzle challenges players to design a single-chain protein with 65-75 residues. The starting structure has 65 residues, but more can be added at a cost of 32 points per residue. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

• 11. Trinity Biology 1 pt. 10,269
• 12. freefolder 1 pt. 9,702
• 13. Minions of TWIS 1 pt. 0
• 14. FoldIt@Netherlands 1 pt. 0

Top soloists

• 1. actiasluna 100 pts. 12,570
• 2. Skippysk8s 96 pts. 12,553
• 3. Mark- 92 pts. 12,455
• 4. Galaxie 87 pts. 12,446
• 5. phi16 83 pts. 12,441
• 6. johnmitch 79 pts. 12,411
• 7. Deleted player pts. 12,404
• 8. reefyrob 72 pts. 12,382
• 9. LociOiling 69 pts. 12,350
• 10. frood66 65 pts. 12,334

Comments

[bkoep]

Residue IE Score (max +500)
Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA, SER, THR in helices.

Residue Count (max +320)
Penalizes extra residues inserted beyond the starting 65, at a cost of 32 points per residue. Players may use up to 75 residues in total.

Secondary Structure (max +500)
No more than 10% of residues may form helices. Extra helices are penalized at 10 points per residue.