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1589: Extra Small Monomer Design

Closed since over 7 years ago

Intermediate Overall Design

Summary

Created
October 17, 2018
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 60-65 residues. The starting structure has 60 residues, but more can be inserted at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Gargleblasters
    1. Gargleblasters
    100 pts. 12,117
  2. Avatar for Anthropic Dreams 2. Anthropic Dreams 74 pts. 12,090
  3. Avatar for Contenders 3. Contenders 54 pts. 12,020
  4. Avatar for Marvin's bunch 4. Marvin's bunch 38 pts. 11,962
  5. Avatar for Beta Folders 5. Beta Folders 27 pts. 11,956
  6. Avatar for Void Crushers 6. Void Crushers 18 pts. 11,928
  7. Avatar for Go Science 7. Go Science 12 pts. 11,813
  8. Avatar for L'Alliance Francophone 8. L'Alliance Francophone 8 pts. 11,646
  9. Avatar for Russian team 9. Russian team 5 pts. 11,244
  10. Avatar for Coastal Biochemistry 10. Coastal Biochemistry 3 pts. 10,800
  1. Avatar for kashton 111. kashton Lv 1 1 pt. 6,475
  2. Avatar for preponi 112. preponi Lv 1 1 pt. 6,249
  3. Avatar for bblattmann 113. bblattmann Lv 1 1 pt. 5,510
  4. Avatar for jshee 114. jshee Lv 1 1 pt. 5,326
  5. Avatar for AndreyTS 115. AndreyTS Lv 1 1 pt. 5,314
  6. Avatar for Benthecrazy 116. Benthecrazy Lv 1 1 pt. 5,313
  7. Avatar for DarkanSoince 117. DarkanSoince Lv 1 1 pt. 5,294
  8. Avatar for abnoeh 118. abnoeh Lv 1 1 pt. 5,264
  9. Avatar for franckpirate 119. franckpirate Lv 1 1 pt. 5,133
  10. Avatar for borroprotein 120. borroprotein Lv 1 1 pt. 5,119

Comments

bkoep Staff Lv 1

Residue IE Score (max +500)
Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Residue Count (max +160)
Penalizes extra residues inserted beyond the starting 60, at a cost of 32 points per residue. Players may use up to 65 residues in total.

Secondary Structure (max +500)
No more than 10% of residues may form helices. Extra helices are penalized at 10 points per residue.