Placeholder image of a protein
Icon representing a puzzle

1573b: HIV Protease Inhibitor Small Molecule Design: Round 3b

Closed since over 7 years ago

Small Molecule Design Pilot

Summary

Created
November 03, 2018
Expires
Max points
100
Description

The goal of this puzzle is to change the chemical structure of the ligand in the center of the protein to find better inhibitors of HIV protease. It's less about changing the protein to fit the ligand, and more about changing the ligand to fit the protein. Use the Ligand Design tool in the selection interface (or the "Ligand Design" mode in the original interface) to alter the chemical identity of the inhibitor.

This is a repost of puzzle 1573, now that issues with hanging in that puzzle should be addressed. The big change on round 3 versus rounds 1 and 2 is how we are scoring the small molecules. We looked at all the interesting designs from previous rounds, and altered scoring (primarily via objectives) to encourage more drug-like small molecules.

See the previous blog post for more information on small molecule design, and Puzzles 1432, 1519 and 1573 for the previous rounds. You should be able to load saved structures from round 2 (puzzle 1519) and round 3 (puzzle 1573) into this puzzle.

Top groups

  1. Avatar for freefolder
    1. freefolder
    100 pts. 21,274
  2. Avatar for Void Crushers 2. Void Crushers 71 pts. 21,136
  3. Avatar for Go Science 3. Go Science 49 pts. 20,795
  4. Avatar for Anthropic Dreams 4. Anthropic Dreams 33 pts. 20,465
  5. Avatar for Beta Folders 5. Beta Folders 22 pts. 20,204
  6. Avatar for Contenders 6. Contenders 14 pts. 20,193
  7. Avatar for Gargleblasters 7. Gargleblasters 8 pts. 19,961
  8. Avatar for Russian team 8. Russian team 5 pts. 19,922
  9. Avatar for L'Alliance Francophone 9. L'Alliance Francophone 3 pts. 19,748
  10. Avatar for Marvin's bunch 10. Marvin's bunch 2 pts. 19,667
  1. Avatar for diamonddays 31. diamonddays Lv 1 30 pts. 19,908
  2. Avatar for NinjaGreg 32. NinjaGreg Lv 1 29 pts. 19,903
  3. Avatar for MurloW 33. MurloW Lv 1 28 pts. 19,890
  4. Avatar for Bruno Kestemont 34. Bruno Kestemont Lv 1 27 pts. 19,874
  5. Avatar for Jesse Pinkman 35. Jesse Pinkman Lv 1 25 pts. 19,865
  6. Avatar for Deleted player 36. Deleted player pts. 19,864
  7. Avatar for ourtown 37. ourtown Lv 1 23 pts. 19,841
  8. Avatar for Mark- 38. Mark- Lv 1 22 pts. 19,832
  9. Avatar for robgee 39. robgee Lv 1 21 pts. 19,813
  10. Avatar for silent gene 40. silent gene Lv 1 20 pts. 19,802

Comments

rmoretti Staff Lv 1

Molecular Weight (max 2000 pts): Penalizes larger (over 630 Da) small molecules.

Number of Rotatable Bonds (max 1000 pts): Penalizes very flexible small molecules. (Click "Show" to highlight rotatable bonds.) Bonds in rings don't count as "rotatable".

Ligand Substructures (max 1000 pts): Penalizes substructures which either occur rarely in drug like molecules, or were over-represented in previous rounds:

  • Peroxides
  • Nitro and nitroso groups
  • Thiols
  • Quaternary amines
  • Amidines </ul> Synthetic Accessibility (max 1000 pts): Penalizes compounds which are harder to make. (Click "Show" to show troublesome areas of the molecule.) Ligand Hydrogen Bond Acceptors (max 1000 pts): Penalizes compounds with too many (14 or more) hydrogen bond acceptors. Ligand Hydrogen Bond Donors (max 1000 pts): Penalizes compounds with too many (7 or more) hydrogen bond donors. Ligand cLogP (max 1000 pts): Penalizes compounds which are too hydrophobic.

JellyJump Lv 1

penalize hydroxylamine functionality as many submissions appear to have this rather reactive functionality in them

Mike Cassidy Lv 1

I keep randomly crashing; here is the crash report:

Process: game_dynamic [1477]
Path: /Applications/Foldit.app/Contents/MacOS/game_dynamic
Identifier: edu.washington.foldit
Version: 1.0
Code Type: X86 (Native)
Parent Process: ??? [1]
Responsible: game_dynamic [1477]
User ID: 501

Date/Time: 2018-11-11 18:20:35.885 -0500
OS Version: Mac OS X 10.14.1 (18B75)
Report Version: 12
Anonymous UUID: 02F110A1-8FE4-6A66-D372-CDB5BC14E36B

Sleep/Wake UUID: FB43E743-06D5-4332-8D1D-467CCE8F8213

Time Awake Since Boot: 28000 seconds
Time Since Wake: 28000 seconds

System Integrity Protection: enabled

Crashed Thread: 0 Dispatch queue: com.apple.main-thread

Exception Type: EXC_CRASH (SIGABRT)
Exception Codes: 0x0000000000000000, 0x0000000000000000
Exception Note: EXC_CORPSE_NOTIFY

Application Specific Information:
terminating with uncaught exception of type utility::excn::Exception:

File: ../src/numeric/xyzVector.hh:665
Cannot normalize xyzVector of length() zero
abort() called

Thread 0 Crashed:: Dispatch queue: com.apple.main-thread
0 libsystem_kernel.dylib 0xa7b52a9a __pthread_kill + 10
1 libsystem_pthread.dylib 0xa7c01165 pthread_kill + 289
2 libsystem_c.dylib 0xa7ab062b abort + 133
3 libc++abi.dylib 0xa5650f27 abort_message + 134
4 libc++abi.dylib 0xa56510d4 default_terminate_handler() + 237
5 game_library.dylib 0x03a06dcb game::application::terminate_handler() + 263
6 libc++abi.dylib 0xa565be1d std::__terminate(void ()()) + 14
7 libc++abi.dylib 0xa565bbde __cxxabiv1::failed_throw(__cxxabiv1::__cxa_exception) + 29
8 libc++abi.dylib 0xa564f7e1 __cxa_throw + 107
9 game_library.dylib 0x013e8148 numeric::xyzVector::normalize() + 280 10 game_library.dylib 0x00d323a5 core::kinematics::Stub::from_four_points(numeric::xyzVector const&, numeric::xyzVector const&, numeric::xyzVector const&, numeric::xyzVector const&) + 55 11 game_library.dylib 0x014151e6 core::scoring::lkball::WaterBuilder::WaterBuilder(numeric::xyzVector const&, core::conformation::Residue const&, unsigned long, unsigned long, unsigned long) + 120 12 game_library.dylib 0x01418584 core::scoring::lkball::setup_water_builders_for_residue_type(core::chemical::ResidueType const&, bool, utility::vector1<utility::vector1<core::scoring::lkball::WaterBuilder, std::__1::allocator >, std::__1::allocator<utility::vector1<core::scoring::lkball::WaterBuilder, std::__1::allocator > > >&) + 470 13 game_library.dylib 0x014191ca core::scoring::lkball::LKBallDatabase::initialize_residue_type(core::chemical::ResidueType const&) + 652 14 game_library.dylib 0x0141a6f7 core::scoring::lkball::LKB_ResidueInfo::initialize(core::chemical::ResidueType const&) + 287 15 game_library.dylib 0x0141a525 core::scoring::lkball::LKB_ResidueInfo::LKB_ResidueInfo(core::conformation::Residue const&) + 171 16 game_library.dylib 0x013fa894 core::scoring::lkball::update_cached_lkb_resinfo(core::conformation::Residue const&, basic::datacache::BasicDataCache&, bool) + 72 17 game_library.dylib 0x013fbfbe core::scoring::lkball::LK_BallEnergy::setup_for_scoring_for_residue(core::conformation::Residue const&, core::pose::Pose const&, core::scoring::ScoreFunction const&, basic::datacache::BasicDataCache&) const + 22 18 game_library.dylib 0x00f67aab core::scoring::ScoreFunction::setup_for_scoring(core::pose::Pose&) const + 461 19 game_library.dylib 0x00f676e4 core::scoring::ScoreFunction::operator()(core::pose::Pose&) const + 260 20 game_library.dylib 0x036e3218 interactive::util::ReferencePoseInfo::score_pose(interactive::util::access_ptr, core::scoring::ScoreFunction&, bool) const + 344 21 game_library.dylib 0x037b3a78 standalone::application::StandaloneApplication::score_pose(interactive::util::access_ptr, bool) + 276 22 game_library.dylib 0x037b9d5b standalone::application::StandaloneApplication::pose_edit() + 141 23 game_library.dylib 0x03a1e229 game::application::GameApplication::pose_edit() + 77 24 game_library.dylib 0x03808286 boost::detail::function::void_function_obj_invoker0<boost::_bi::bind_t<void, boost::_mfi::mf0<void, standalone::application::StandaloneApplication>, boost::_bi::list1<boost::_bi::value<standalone::application::StandaloneApplication*> > >, void>::invoke(boost::detail::function::function_buffer&) + 32 25 game_library.dylib 0x035e9e03 boost::function0::operator()() const + 35 26 game_library.dylib 0x036e853d interactive::util::WrappedPose::call_edit_callback() + 109 27 game_library.dylib 0x034864fb interactive::application::actions::ligand::update_game_ligand_(interactive::util::access_ptr, boost::shared_ptr, unsigned long, bool) + 344 28 game_library.dylib 0x03486a11 interactive::application::actions::ligand::update_ligand(interactive::util::access_ptr, boost::shared_ptr, unsigned long, bool, bool, bool) + 250 29 game_library.dylib 0x0347e962 interactive::application::actions::ligand::ActionReplaceAtom::on_instant_run() + 698 30 game_library.dylib 0x035702c5 interactive::application::shared::ToolActionInstant::do_launch() + 51 31 game_library.dylib 0x0356f4a4 interactive::application::shared::ToolAction::launch() + 188 32 game_library.dylib 0x0348492b interactive::application::actions::ligand::ActionReplaceAtomFloatMenu::on_clickity_clackity(core::chemical::element::Elements const&) + 273 33 game_library.dylib 0x034856da boost::detail::function::void_function_obj_invoker0<boost::_bi::bind_t<void, boost::_mfi::mf1<void, interactive::application::actions::ligand::ActionReplaceAtomFloatMenu, core::chemical::element::Elements const&>, boost::_bi::list2<boost::_bi::value<interactive::application::actions::ligand::ActionReplaceAtomFloatMenu*>, boost::_bi::value > >, void>::invoke(boost::detail::function::function_buffer&) + 38 34 game_library.dylib 0x035e9e03 boost::function0::operator()() const + 35 35 game_library.dylib 0x03622449 interactive::gui::Button::on_click() + 47 36 game_library.dylib 0x03620fa7 interactive::gui::Button::generate_click() + 55 37 game_library.dylib 0x036224fb interactive::gui::Button::on_mouse_up(interactive::gui::Point2D const&, int) + 63 38 game_library.dylib 0x0365a2e8 interactive::gui::TopLevel::on_mouse_up(interactive::gui::Point2D const&, int) + 162 39 game_library.dylib 0x0366cd4c interactive::guiwrapper::GUIWrapper::generic_mouse_button_func(int, bool, int, int) + 260 40 game_library.dylib 0x03674330 void boost::_bi::list5<boost::_bi::value<interactive::guiwrapper::cocoa::CocoaWrapper*>, boost::_bi::value, boost::_bi::value, boost::_bi::value, boost::_bi::value >::operator()<boost::_mfi::mf4<void, interactive::guiwrapper::GUIWrapper, int, bool, int, int>, boost::_bi::list0>(boost::_bi::type, boost::_mfi::mf4<void, interactive::guiwrapper::GUIWrapper, int, bool, int, int>&, boost::_bi::list0&, int) + 64 41 game_library.dylib 0x036742eb boost::detail::function::void_function_obj_invoker0<boost::_bi::bind_t<void, boost::_mfi::mf4<void, interactive::guiwrapper::GUIWrapper, int, bool, int, int>, boost::_bi::list5<boost::_bi::value<interactive::guiwrapper::cocoa::CocoaWrapper*>, boost::_bi::value, boost::_bi::value, boost::_bi::value, boost::_bi::value > >, void>::invoke(boost::detail::function::function_buffer&) + 27 42 game_library.dylib 0x035e9e03 boost::function0::operator()() const + 35 43 game_library.dylib 0x0366caf5 interactive::guiwrapper::GUIWrapper::enqueue_event(boost::function<void ()>) + 41 44 game_library.dylib 0x03672429 cocoa_wrapper_mouse_button + 296 45 game_library.dylib 0x03671bd0 -[CocoaOpenGLView anyMouseUp:withButton:] + 121 46 game_library.dylib 0x03671895 -[CocoaOpenGLView mouseUp:] + 31 47 com.apple.AppKit 0x91639a9a -[NSWindow(NSEventRouting) _reallySendEvent:isDelayedEvent:] + 593 48 com.apple.AppKit 0x9163960b -[NSWindow(NSEventRouting) sendEvent:] + 427 49 com.apple.AppKit 0x914e500d -[NSApplication(NSEvent) sendEvent:] + 3521 50 com.apple.AppKit 0x914d2a4e -[NSApplication run] + 826 51 game_library.dylib 0x03674f7a cocoa_glue_start + 981 52 game_library.dylib 0x03673581 interactive::guiwrapper::cocoa::CocoaWrapper::start() + 39 53 game_library.dylib 0x03406871 interactive::application::interactive_main(utility::vector1<std::__1::basic_string<char, std::__1::char_traits, std::__1::allocator >, std::__1::allocator<std::__1::basic_string<char, std::__1::char_traits, std::__1::allocator > > > const&, boost::function<interactive::guiwrapper::Application* ()>, boost::function<void ()>, bool) + 4412 54 game_library.dylib 0x03aa2148 game::application::game_main(int, char**, char const*, game::application::ExecutableKindEnum) + 2328 55 game_library.dylib 0x0022e7d0 library_main + 32 56 edu.washington.foldit 0x000ac25a run_library_main(std::__1::basic_string<char, std::__1::char_traits, std::__1::allocator > const&, bool, std::__1::basic_string<char, std::__1::char_traits, std::__1::allocator > const&, int&, int, char**, std::__1::basic_string<char, std::__1::char_traits, std::__1::allocator >&) + 170 57 edu.washington.foldit 0x000abef2 main + 319 58 edu.washington.foldit 0x000a9605 start + 53

Thread 1:
0 libsystem_pthread.dylib 0xa7bfd7c0 start_wqthread + 0
1 ??? 0x54485244 0 + 1414025796

Thread 2:
0 libsystem_pthread.dylib 0xa7bfd7c0 start_wqthread + 0
1 ??? 0x54485244 0 + 1414025796

Thread 3:: com.apple.audio.IOThread.client
0 libsystem_kernel.dylib 0xa7b4ce22 mach_msg_trap + 10
1 libsystem_kernel.dylib 0xa7b4d35f mach_msg + 47
2 com.apple.audio.CoreAudio 0x934e7a82 HALB_MachPort::SendMessageWithReply(unsigned int, unsigned int, unsigned long, unsigned long, mach_msg_header_t, bool, unsigned int) + 126
3 com.apple.audio.CoreAudio 0x934bfc3b HALB_MachPort::SendSimpleMessageWithSimpleReply(unsigned int, unsigned int, int, int&, bool, unsigned int) + 49
4 com.apple.audio.CoreAudio 0x934bcbcb HALC_ProxyIOContext::IOWorkLoop() + 1589
5 com.apple.audio.CoreAudio 0x934bc342 HALC_ProxyIOContext::IOThreadEntry(void) + 236
6 com.apple.audio.CoreAudio 0x934f06d0 invocation function for block in HALC_ProxyIOContext::HALC_ProxyIOContext(unsigned long, unsigned int) + 20
7 com.apple.audio.CoreAudio 0x934bbfcf HALB_IOThread::Entry(void*) + 71
8 libsystem_pthread.dylib 0xa7bfe648 _pthread_body + 137
9 libsystem_pthread.dylib 0xa7c01837 _pthread_start + 82
10 libsystem_pthread.dylib 0xa7bfd806 thread_start + 34

Thread 4:: com.apple.NSEventThread
0 libsystem_kernel.dylib 0xa7b4ce22 mach_msg_trap + 10
1 libsystem_kernel.dylib 0xa7b4d35f mach_msg + 47
2 com.apple.CoreFoundation 0x938e8ad9 __CFRunLoopServiceMachPort + 289
3 com.apple.CoreFoundation 0x938e819a __CFRunLoopRun + 3196
4 com.apple.CoreFoundation 0x938e7221 CFRunLoopRunSpecific + 584
5 com.apple.CoreFoundation 0x9390021f CFRunLoopRunInMode + 82
6 com.apple.AppKit 0x914e1bf3 _NSEventThread + 165
7 libsystem_pthread.dylib 0xa7bfe648 _pthread_body + 137
8 libsystem_pthread.dylib 0xa7c01837 _pthread_start + 82
9 libsystem_pthread.dylib 0xa7bfd806 thread_start + 34

Thread 5:
0 libsystem_kernel.dylib 0xa7b50792 __semwait_signal + 10
1 libsystem_c.dylib 0xa7acdd97 nanosleep$UNIX2003 + 189
2 libsystem_c.dylib 0xa7acdc84 usleep$UNIX2003 + 54
3 game_library.dylib 0x036e75c7 interactive::util::Thread::sleep(double) + 47
4 game_library.dylib 0x0352a3c1 interactive::application::appposeview::VoidGeom::VoidThread::operator()() + 123
5 game_library.dylib 0x036e77c3 interactive::util::Thread::thread_entry_func() + 31
6 game_library.dylib 0x036e726d interactive::util::Thread::pthread_startup_helper(void*) + 33
7 libsystem_pthread.dylib 0xa7bfe648 _pthread_body + 137
8 libsystem_pthread.dylib 0xa7c01837 _pthread_start + 82
9 libsystem_pthread.dylib 0xa7bfd806 thread_start + 34

Thread 6:
0 libsystem_kernel.dylib 0xa7b4f992 __psynch_mutexwait + 10
1 libsystem_pthread.dylib 0xa7bff091 _pthread_mutex_firstfit_lock_wait + 95
2 libsystem_pthread.dylib 0xa7bfc7dd _pthread_mutex_firstfit_lock_slow + 343
3 libsystem_pthread.dylib 0xa7bfc450 pthread_mutex_lock + 146
4 game_library.dylib 0x038e8106 boost::unique_lock::lock() + 38 5 game_library.dylib 0x0351f09f interactive::application::appposeview::HydrophobicComposite::HydroThread::operator()() + 49 6 game_library.dylib 0x036e77c3 interactive::util::Thread::thread_entry_func() + 31 7 game_library.dylib 0x036e726d interactive::util::Thread::pthread_startup_helper(void*) + 33 8 libsystem_pthread.dylib 0xa7bfe648 _pthread_body + 137 9 libsystem_pthread.dylib 0xa7c01837 _pthread_start + 82 10 libsystem_pthread.dylib 0xa7bfd806 thread_start + 34

Thread 7:
0 libsystem_kernel.dylib 0xa7b50792 __semwait_signal + 10
1 libsystem_c.dylib 0xa7acdd97 nanosleep$UNIX2003 + 189
2 libsystem_c.dylib 0xa7acdc84 usleep$UNIX2003 + 54
3 game_library.dylib 0x036e75c7 interactive::util::Thread::sleep(double) + 47
4 game_library.dylib 0x03526eb8 interactive::application::appposeview::ResidueBurialComposite::ResidueBurialThread::operator()() + 176
5 game_library.dylib 0x036e77c3 interactive::util::Thread::thread_entry_func() + 31
6 game_library.dylib 0x036e726d interactive::util::Thread::pthread_startup_helper(void*) + 33
7 libsystem_pthread.dylib 0xa7bfe648 _pthread_body + 137
8 libsystem_pthread.dylib 0xa7c01837 _pthread_start + 82
9 libsystem_pthread.dylib 0xa7bfd806 thread_start + 34

Thread 8:
0 libsystem_kernel.dylib 0xa7b50792 __semwait_signal + 10
1 libsystem_c.dylib 0xa7acdd97 nanosleep$UNIX2003 + 189
2 libsystem_c.dylib 0xa7acdc84 usleep$UNIX2003 + 54
3 game_library.dylib 0x036e75c7 interactive::util::Thread::sleep(double) + 47
4 game_library.dylib 0x037c9bb5 standalone::application::StandaloneApplication::autosave_thread_body() + 53
5 game_library.dylib 0x03808286 boost::detail::function::void_function_obj_invoker0<boost::_bi::bind_t<void, boost::_mfi::mf0<void, standalone::application::StandaloneApplication>, boost::_bi::list1<boost::_bi::value<standalone::application::StandaloneApplication*> > >, void>::invoke(boost::detail::function::function_buffer&) + 32
6 game_library.dylib 0x035e9e03 boost::function0::operator()() const + 35 7 game_library.dylib 0x036e75f9 interactive::util::Thread::operator()() + 45 8 game_library.dylib 0x036e77c3 interactive::util::Thread::thread_entry_func() + 31 9 game_library.dylib 0x036e726d interactive::util::Thread::pthread_startup_helper(void*) + 33 10 libsystem_pthread.dylib 0xa7bfe648 _pthread_body + 137 11 libsystem_pthread.dylib 0xa7c01837 _pthread_start + 82 12 libsystem_pthread.dylib 0xa7bfd806 thread_start + 34

Thread 9:
0 libsystem_kernel.dylib 0xa7b4f992 __psynch_mutexwait + 10
1 libsystem_pthread.dylib 0xa7bff091 _pthread_mutex_firstfit_lock_wait + 95
2 libsystem_pthread.dylib 0xa7bfc7dd _pthread_mutex_firstfit_lock_slow + 343
3 libsystem_pthread.dylib 0xa7bfc450 pthread_mutex_lock + 146
4 game_library.dylib 0x038e8106 boost::unique_lock::lock() + 38 5 game_library.dylib 0x039e04aa game::application::BoincThread::send_boinc(game::application::PollOverride) + 122 6 game_library.dylib 0x039e0002 game::application::BoincThread::periodically_send_and_check_boinc() + 78 7 game_library.dylib 0x036e77c3 interactive::util::Thread::thread_entry_func() + 31 8 game_library.dylib 0x036e726d interactive::util::Thread::pthread_startup_helper(void*) + 33 9 libsystem_pthread.dylib 0xa7bfe648 _pthread_body + 137 10 libsystem_pthread.dylib 0xa7c01837 _pthread_start + 82 11 libsystem_pthread.dylib 0xa7bfd806 thread_start + 34

Thread 10:
0 libsystem_kernel.dylib 0xa7b53cea __select + 10
1 game_library.dylib 0x03b0e6be game::util::IRC::run(boost::function<bool ()>) + 1426
2 game_library.dylib 0x03a3c31a game::application::IRCThread::operator()() + 1006
3 game_library.dylib 0x036e77c3 interactive::util::Thread::thread_entry_func() + 31
4 game_library.dylib 0x036e726d interactive::util::Thread::pthread_startup_helper(void*) + 33
5 libsystem_pthread.dylib 0xa7bfe648 _pthread_body + 137
6 libsystem_pthread.dylib 0xa7c01837 _pthread_start + 82
7 libsystem_pthread.dylib 0xa7bfd806 thread_start + 34

Thread 11:
0 libsystem_pthread.dylib 0xa7bfd7c0 start_wqthread + 0
1 ??? 0x54485244 0 + 1414025796

Thread 12:
0 game_library.dylib 0x00538ed8 DistGeom::DistViolationContrib::getGrad(double, double) const + 298
1 game_library.dylib 0x004f129b ForceFields::ForceField::calcGrad(double, double) + 85
2 game_library.dylib 0x004f1a10 ForceFieldsHelper::calcGradient::operator()(double, double) const + 66
3 game_library.dylib 0x004f013c int BFGSOpt::minimize<ForceFieldsHelper::calcEnergy, ForceFieldsHelper::calcGradient>(unsigned int, double, double, unsigned int&, double&, ForceFieldsHelper::calcEnergy, ForceFieldsHelper::calcGradient, double, unsigned int) + 823
4 game_library.dylib 0x004ef834 ForceFields::ForceField::minimize(unsigned int, double, double) + 184
5 game_library.dylib 0x005206a3 RDKit::DGeomHelpers::_embedPoints(std::__1::vector<RDGeom::Point, std::__1::allocator<RDGeom::Point> >, boost::shared_ptr, bool, double, bool, unsigned int, double, double, int, unsigned int, std::__1::vector<boost::shared_ptr, std::__1::allocator<boost::shared_ptr > > const*, bool, bool, bool, std::__1::vector<std::__1::pair<int, int>, std::__1::allocator<std::__1::pair<int, int> > > const&, std::__1::vector<std::__1::vector<int, std::__1::allocator >, std::__1::allocator<std::__1::vector<int, std::__1::allocator > > > const&, std::__1::vector<std::__1::vector<int, std::__1::allocator >, std::__1::allocator<std::__1::vector<int, std::__1::allocator > > > const&, std::__1::vector<std::__1::pair<std::__1::vector<int, std::__1::allocator >, std::__1::vector<double, std::__1::allocator > >, std::__1::allocator<std::__1::pair<std::__1::vector<int, std::__1::allocator >, std::__1::vector<double, std::__1::allocator > > > > const&, std::__1::vector<std::__1::vector<int, std::__1::allocator >, std::__1::allocator<std::__1::vector<int, std::__1::allocator > > > const&, std::__1::vector<int, std::__1::allocator > const&) + 613 6 game_library.dylib 0x0052302d RDKit::DGeomHelpers::detail::embedHelper_(int, int, RDKit::DGeomHelpers::detail::EmbedArgs*) + 577 7 game_library.dylib 0x005221f8 RDKit::DGeomHelpers::EmbedMultipleConfs(RDKit::ROMol&, std::__1::vector<int, std::__1::allocator >&, unsigned int, int, unsigned int, int, bool, bool, double, bool, unsigned int, double, std::__1::map<int, RDGeom::Point3D, std::__1::less, std::__1::allocator<std::__1::pair<int const, RDGeom::Point3D> > > const*, double, bool, bool, bool, bool, bool, double) + 2434 8 game_library.dylib 0x01ed0d0b protocols::fragment_rotamers::RDKitRotamers::generate_conformers(core::chemical::ResidueType const&, unsigned long, bool, std::__1::atomic*) + 315 9 game_library.dylib 0x03730b00 interactive::util::ligand::ThreadedRDKitRotamerLibrarySpecification::generate_library(core::chemical::ResidueType const&) + 76 10 game_library.dylib 0x037312ce boost::detail::function::void_function_obj_invoker0<boost::_bi::bind_t<void, boost::_mfi::mf1<void, interactive::util::ligand::ThreadedRDKitRotamerLibrarySpecification, core::chemical::ResidueType const&>, boost::_bi::list2<boost::_bi::value<interactive::util::ligand::ThreadedRDKitRotamerLibrarySpecification*>, boost::_bi::value > >, void>::invoke(boost::detail::function::function_buffer&) + 38 11 game_library.dylib 0x035e9e03 boost::function0::operator()() const + 35 12 game_library.dylib 0x036e75f9 interactive::util::Thread::operator()() + 45 13 game_library.dylib 0x036e77c3 interactive::util::Thread::thread_entry_func() + 31 14 game_library.dylib 0x036e726d interactive::util::Thread::pthread_startup_helper(void*) + 33 15 libsystem_pthread.dylib 0xa7bfe648 _pthread_body + 137 16 libsystem_pthread.dylib 0xa7c01837 _pthread_start + 82 17 libsystem_pthread.dylib 0xa7bfd806 thread_start + 34

Thread 0 crashed with X86 Thread State (32-bit):
eax: 0x00000000 ebx: 0x001eea40 ecx: 0xbff56dcc edx: 0x00000000
edi: 0xa7c01052 esi: 0x0000002d ebp: 0xbff56de8 esp: 0xbff56dcc
ss: 0x00000023 efl: 0x00000206 eip: 0xa7b52a9a cs: 0x0000000b
ds: 0x00000023 es: 0x00000023 fs: 0x00000000 gs: 0x0000000f
cr2: 0xa9ecf360

Logical CPU: 0
Error Code: 0x00080148
Trap Number: 132

Binary Images:
0xa8000 - 0xadffb +edu.washington.foldit (1.0) /Applications/Foldit.app/Contents/MacOS/game_dynamic 0x1a8000 - 0x1ecacf dyld (635.2) /usr/lib/dyld 0x22d000 - 0x4dfdff7 +game_library.dylib (1) /Applications/Foldit.app/Contents/Resources/cmp-binary-013106a6d1e90f252e6eff463f193a5e/game_library.dylib 0xb5ce000 - 0xb5d1047 libobjc-trampolines.dylib (750.1) <57098857-AC21-369F-94CD-3CFC8AFE060A> /usr/lib/libobjc-trampolines.dylib 0xb603000 - 0xb607ff7 com.apple.audio.AppleHDAHALPlugIn (282.10 - 282.10) /System/Library/Extensions/AppleHDA.kext/Contents/PlugIns/AppleHDAHALPlugIn.bundle/Contents/MacOS/AppleHDAHALPlugIn 0xc3bf000 - 0xc553fff GLEngine (17.0.37) <8F886BC1-D6BC-36AF-AE77-B5C26275B41F> /System/Library/Frameworks/OpenGL.framework/Resources/GLEngine.bundle/GLEngine 0xc594000 - 0xcaccff7 com.apple.driver.AppleIntelHD5000GraphicsGLDriver (12.2.17 - 12.0.2) <70C05E6D-53D9-36F3-9F78-67B1A58548E3> /System/Library/Extensions/AppleIntelHD5000GraphicsGLDriver.bundle/Contents/MacOS/AppleIntelHD5000GraphicsGLDriver 0xccb8000 - 0xd5feff3 com.apple.GeForceGLDriver (12.0.19 - 12.0.0) <945208A7-2539-33C7-8687-E5F9387E9DBC> /System/Library/Extensions/GeForceGLDriver.bundle/Contents/MacOS/GeForceGLDriver 0xdbcd000 - 0xe2a9fff libclh.dylib (12.0.19) /System/Library/Extensions/GeForceGLDriver.bundle/Contents/MacOS/libclh.dylib 0xe2ee000 - 0xe4a7ff3 com.apple.audio.units.Components (1.14 - 1.14) /System/Library/Components/CoreAudio.component/Contents/MacOS/CoreAudio 0x90015000 - 0x9001cfff com.apple.agl (3.3.2 - AGL-3.3.2) /System/Library/Frameworks/AGL.framework/Versions/A/AGL 0x902be000 - 0x902befff com.apple.Accelerate (1.11 - Accelerate 1.11) <511606EC-E003-3978-BB40-5F8F2D16C03C> /System/Library/Frameworks/Accelerate.framework/Versions/A/Accelerate 0x902bf000 - 0x902d4ffb libCGInterfaces.dylib (506.19.1) /System/Library/Frameworks/Accelerate.framework/Versions/A/Frameworks/vImage.framework/Versions/A/Libraries/libCGInterfaces.dylib 0x902d5000 - 0x90bccfd3 com.apple.vImage (8.1 - ???) /System/Library/Frameworks/Accelerate.framework/Versions/A/Frameworks/vImage.framework/Versions/A/vImage 0x90bcd000 - 0x90ceafdb libBLAS.dylib (1243.200.4) /System/Library/Frameworks/Accelerate.framework/Versions/A/Frameworks/vecLib.framework/Versions/A/libBLAS.dylib 0x90ceb000 - 0x90d25ffb libBNNS.dylib (38.200.5) <154F2951-EC8B-3D79-A82A-3E9B40E073E2> /System/Library/Frameworks/Accelerate.framework/Versions/A/Frameworks/vecLib.framework/Versions/A/libBNNS.dylib 0x90d26000 - 0x9107bffb libLAPACK.dylib (1243.200.4) /System/Library/Frameworks/Accelerate.framework/Versions/A/Frameworks/vecLib.framework/Versions/A/libLAPACK.dylib 0x9107c000 - 0x91091ffb libLinearAlgebra.dylib (1243.200.4) /System/Library/Frameworks/Accelerate.framework/Versions/A/Frameworks/vecLib.framework/Versions/A/libLinearAlgebra.dylib 0x91092000 - 0x910abfff libSparseBLAS.dylib (1243.200.4) /System/Library/Frameworks/Accelerate.framework/Versions/A/Frameworks/vecLib.framework/Versions/A/libSparseBLAS.dylib 0x910ac000 - 0x91240fcb libvDSP.dylib (671.220.1) /System/Library/Frameworks/Accelerate.framework/Versions/A/Frameworks/vecLib.framework/Versions/A/libvDSP.dylib 0x91241000 - 0x91406fe7 libvMisc.dylib (671.220.1) <5B6EC57D-5A5B-3B3F-865E-76AC2E81E88D> /System/Library/Frameworks/Accelerate.framework/Versions/A/Frameworks/vecLib.framework/Versions/A/libvMisc.dylib 0x91407000 - 0x91407fff com.apple.Accelerate.vecLib (3.11 - vecLib 3.11) /System/Library/Frameworks/Accelerate.framework/Versions/A/Frameworks/vecLib.framework/Versions/A/vecLib 0x914c0000 - 0x9225fffb com.apple.AppKit (6.9 - 1671.10.106) /System/Library/Frameworks/AppKit.framework/Versions/C/AppKit 0x922b1000 - 0x922b1fff com.apple.ApplicationServices (50.1 - 50.1) <967AD1E9-56A6-346F-9569-B9D57D0CD513> /System/Library/Frameworks/ApplicationServices.framework/Versions/A/ApplicationServices 0x922b2000 - 0x9231dff3 com.apple.ApplicationServices.ATS (377 - 453.11) <09D294F9-24EE-31E0-A0E8-3AE89DE83A5F> /System/Library/Frameworks/ApplicationServices.framework/Versions/A/Frameworks/ATS.framework/Versions/A/ATS 0x92320000 - 0x92440ffb libFontParser.dylib (228.6) <62F86190-611D-30C3-AE5F-408CD776DB99> /System/Library/Frameworks/ApplicationServices.framework/Versions/A/Frameworks/ATS.framework/Versions/A/Resources/libFontParser.dylib 0x92441000 - 0x9248efff libFontRegistry.dylib (228.12) <5A42084E-C734-3497-9FF4-026FBAE4BCA4> /System/Library/Frameworks/ApplicationServices.framework/Versions/A/Frameworks/ATS.framework/Versions/A/Resources/libFontRegistry.dylib 0x924dd000 - 0x9250fff7 libTrueTypeScaler.dylib (228.6) <1C25432A-C5E0-30E0-969D-74687D78AEA5> /System/Library/Frameworks/ApplicationServices.framework/Versions/A/Frameworks/ATS.framework/Versions/A/Resources/libTrueTypeScaler.dylib 0x9257b000 - 0x92580fff com.apple.ColorSyncLegacy (4.13.0 - 1) /System/Library/Frameworks/ApplicationServices.framework/Versions/A/Frameworks/ColorSyncLegacy.framework/Versions/A/ColorSyncLegacy 0x92627000 - 0x9267ffff com.apple.HIServices (1.22 - 627.14.2) <393FAF3C-19E4-31C3-BD1D-7886EDF9FC80> /System/Library/Frameworks/ApplicationServices.framework/Versions/A/Frameworks/HIServices.framework/Versions/A/HIServices 0x92680000 - 0x9268efff com.apple.LangAnalysis (1.7.0 - 1.7.0) <67BF73AC-488D-3E02-B946-6E36D00BA308> /System/Library/Frameworks/ApplicationServices.framework/Versions/A/Frameworks/LangAnalysis.framework/Versions/A/LangAnalysis 0x9268f000 - 0x926e6fff com.apple.print.framework.PrintCore (14.0 - 503.7) <3B044046-6955-3A0A-9047-3FBA020EFBC5> /System/Library/Frameworks/ApplicationServices.framework/Versions/A/Frameworks/PrintCore.framework/Versions/A/PrintCore 0x926e7000 - 0x92782ffb com.apple.QD (3.12 - 407.2) <37BEAEA5-7F30-3B9E-8A60-B2A2ED29FE6A> /System/Library/Frameworks/ApplicationServices.framework/Versions/A/Frameworks/QD.framework/Versions/A/QD 0x92783000 - 0x9278fff7 com.apple.speech.synthesis.framework (8.1.0 - 8.1.0) <899109E1-8C15-3CFE-A9E9-A507B1737200> /System/Library/Frameworks/ApplicationServices.framework/Versions/A/Frameworks/SpeechSynthesis.framework/Versions/A/SpeechSynthesis 0x92790000 - 0x929dbfff com.apple.audio.toolbox.AudioToolbox (1.14 - 1.14) <174559D3-F922-37D3-AAEC-21C7B0FD9A97> /System/Library/Frameworks/AudioToolbox.framework/Versions/A/AudioToolbox 0x929dd000 - 0x929ddfff com.apple.audio.units.AudioUnit (1.14 - 1.14) <3AD1A040-BE73-32A8-A52C-E1C21D13A09B> /System/Library/Frameworks/AudioUnit.framework/Versions/A/AudioUnit 0x92b13000 - 0x92ea7fff com.apple.CFNetwork (975.0.3 - 975.0.3) <8FD64881-A6BC-3B2C-8705-5D5388810070> /System/Library/Frameworks/CFNetwork.framework/Versions/A/CFNetwork 0x92ebc000 - 0x92ebcfff com.apple.Carbon (158 - 158) /System/Library/Frameworks/Carbon.framework/Versions/A/Carbon 0x92ebd000 - 0x92ec6ff7 com.apple.audio.SoundManager (4.2 - 4.2) <6E51BBAA-232A-3403-87FC-B7047A3D2A5C> /System/Library/Frameworks/Carbon.framework/Versions/A/Frameworks/CarbonSound.framework/Versions/A/CarbonSound 0x92ec7000 - 0x92ecbff3 com.apple.CommonPanels (1.2.6 - 98) /System/Library/Frameworks/Carbon.framework/Versions/A/Frameworks/CommonPanels.framework/Versions/A/CommonPanels 0x92ecc000 - 0x93260ff7 com.apple.HIToolbox (2.1.1 - 917.2) <97364C36-08D1-333F-81EB-E8C1806FA9F4> /System/Library/Frameworks/Carbon.framework/Versions/A/Frameworks/HIToolbox.framework/Versions/A/HIToolbox 0x93261000 - 0x932b6ff7 com.apple.htmlrendering (77 - 1.1.4) <221C0D9F-9227-3282-A353-417718693FCD> /System/Library/Frameworks/Carbon.framework/Versions/A/Frameworks/HTMLRendering.framework/Versions/A/HTMLRendering 0x932b7000 - 0x932bafff com.apple.help (1.3.8 - 66) <5366D119-5BEA-33C8-8596-FA0435255653> /System/Library/Frameworks/Carbon.framework/Versions/A/Frameworks/Help.framework/Versions/A/Help 0x932bb000 - 0x932c0fff com.apple.ImageCapture (9.0 - 1530.1) /System/Library/Frameworks/Carbon.framework/Versions/A/Frameworks/ImageCapture.framework/Versions/A/ImageCapture 0x932c1000 - 0x9335bff7 com.apple.ink.framework (10.9 - 225) /System/Library/Frameworks/Carbon.framework/Versions/A/Frameworks/Ink.framework/Versions/A/Ink 0x9335c000 - 0x93396ff7 com.apple.NavigationServices (3.8 - 227) <136C9EF8-D817-3AE0-85FE-AAE952578023> /System/Library/Frameworks/Carbon.framework/Versions/A/Frameworks/NavigationServices.framework/Versions/A/NavigationServices 0x93397000 - 0x933b3ff7 com.apple.openscripting (1.7 - 179) <0D4E7E7D-9C09-3ABB-B384-F1C6FD0D58D1> /System/Library/Frameworks/Carbon.framework/Versions/A/Frameworks/OpenScripting.framework/Versions/A/OpenScripting 0x933b4000 - 0x933b8ffb com.apple.print.framework.Print (14.0 - 267.3) <17FB2FB1-2860-3DD2-92A6-C15BB3566C0D> /System/Library/Frameworks/Carbon.framework/Versions/A/Frameworks/Print.framework/Versions/A/Print 0x933b9000 - 0x933bbffb com.apple.securityhi (9.0 - 55006) /System/Library/Frameworks/Carbon.framework/Versions/A/Frameworks/SecurityHI.framework/Versions/A/SecurityHI 0x933bc000 - 0x933c2ffb com.apple.speech.recognition.framework (6.0.3 - 6.0.3) <427349F6-0B5A-36D4-9FA9-F7BDAAC1BDE9> /System/Library/Frameworks/Carbon.framework/Versions/A/Frameworks/SpeechRecognition.framework/Versions/A/SpeechRecognition 0x933c3000 - 0x933c3fff com.apple.Cocoa (6.11 - 23) <281070CB-D9A7-3A27-A735-E35147659169> /System/Library/Frameworks/Cocoa.framework/Versions/A/Cocoa 0x933d0000 - 0x934a3ff3 com.apple.ColorSync (4.13.0 - 3340) /System/Library/Frameworks/ColorSync.framework/Versions/A/ColorSync 0x934a4000 - 0x9353bffb com.apple.audio.CoreAudio (4.3.0 - 4.3.0) <0194A8E9-A3FD-3A6C-A2E2-48D31226AEB5> /System/Library/Frameworks/CoreAudio.framework/Versions/A/CoreAudio 0x93598000 - 0x9359dfff com.apple.CoreBluetooth (1.0 - 1) /System/Library/Frameworks/CoreBluetooth.framework/Versions/A/CoreBluetooth 0x9359e000 - 0x938a5ff3 com.apple.CoreData (120 - 866.1) <83541894-3C8A-34B4-A4CF-968CADC2EEA2> /System/Library/Frameworks/CoreData.framework/Versions/A/CoreData 0x938a6000 - 0x938acfff com.apple.CoreDisplay (101.3 - 104.4) <2A5B7365-0B46-3815-B542-74B3D0612B46> /System/Library/Frameworks/CoreDisplay.framework/Versions/A/CoreDisplay 0x938ad000 - 0x93ceeffb com.apple.CoreFoundation (6.9 - 1560.12) <3AAB18EB-3737-37DD-8FD2-28092A1B7D36> /System/Library/Frameworks/CoreFoundation.framework/Versions/A/CoreFoundation 0x93cf0000 - 0x943a7fff com.apple.CoreGraphics (2.0 - 1247.4.1) <95B6F914-6057-3794-88F6-60F81706D4CC> /System/Library/Frameworks/CoreGraphics.framework/Versions/A/CoreGraphics 0x943a9000 - 0x9465bff3 com.apple.CoreImage (14.1.0 - 710.2.240) <224C0833-A8B2-3F7C-91E8-2F9154522144> /System/Library/Frameworks/CoreImage.framework/Versions/A/CoreImage 0x948af000 - 0x948affff com.apple.CoreServices (934 - 934) <10C6D963-2C8E-34F9-809A-FE36B6599A18> /System/Library/Frameworks/CoreServices.framework/Versions/A/CoreServices 0x948b0000 - 0x9492dff7 com.apple.AE (771 - 771) <2B1B26D2-723E-3B9A-8762-52DF7553D2D5> /System/Library/Frameworks/CoreServices.framework/Versions/A/Frameworks/AE.framework/Versions/A/AE 0x9492e000 - 0x94c0efff com.apple.CoreServices.CarbonCore (1178.11 - 1178.11) <6AB97C1C-B68B-3022-A54A-4FDF4BBF6EFD> /System/Library/Frameworks/CoreServices.framework/Versions/A/Frameworks/CarbonCore.framework/Versions/A/CarbonCore 0x94c0f000 - 0x94c58fff com.apple.DictionaryServices (1.2 - 284.16.3) <06163D84-177D-3CE0-9B70-8CFB2ECA5CBD> /System/Library/Frameworks/CoreServices.framework/Versions/A/Frameworks/DictionaryServices.framework/Versions/A/DictionaryServices 0x94c59000 - 0x94c61fff com.apple.CoreServices.FSEvents (1239.200.12 - 1239.200.12) /System/Library/Frameworks/CoreServices.framework/Versions/A/Frameworks/FSEvents.framework/Versions/A/FSEvents 0x94c62000 - 0x94dc8fff com.apple.LaunchServices (934 - 934) <9E8DE093-CEBC-39BB-A463-6E7D11F0EA94> /System/Library/Frameworks/CoreServices.framework/Versions/A/Frameworks/LaunchServices.framework/Versions/A/LaunchServices 0x94dc9000 - 0x94e6affb com.apple.Metadata (10.7.0 - 1191.52) <0B65A889-1EE8-39D1-BA6B-C9C7B1F0FF0F> /System/Library/Frameworks/CoreServices.framework/Versions/A/Frameworks/Metadata.framework/Versions/A/Metadata 0x94e6b000 - 0x94eb7fff com.apple.CoreServices.OSServices (934 - 934) /System/Library/Frameworks/CoreServices.framework/Versions/A/Frameworks/OSServices.framework/Versions/A/OSServices 0x94eb8000 - 0x94f28ffb com.apple.SearchKit (1.4.0 - 1.4.0) /System/Library/Frameworks/CoreServices.framework/Versions/A/Frameworks/SearchKit.framework/Versions/A/SearchKit 0x94f29000 - 0x94f4cfff com.apple.coreservices.SharedFileList (71.27 - 71.27) <7457D674-A87F-3F77-8258-551C7721AC77> /System/Library/Frameworks/CoreServices.framework/Versions/A/Frameworks/SharedFileList.framework/Versions/A/SharedFileList 0x94f4d000 - 0x950a8ffb com.apple.CoreText (352.0 - 584.25) <74918E91-0D5C-3A22-94D8-5EF433770887> /System/Library/Frameworks/CoreText.framework/Versions/A/CoreText 0x950a9000 - 0x950e6ffb com.apple.CoreVideo (1.8 - 0.0) /System/Library/Frameworks/CoreVideo.framework/Versions/A/CoreVideo 0x950e7000 - 0x9517bff3 com.apple.framework.CoreWLAN (13.0 - 1370.8) /System/Library/Frameworks/CoreWLAN.framework/Versions/A/CoreWLAN 0x9526b000 - 0x95274ffb com.apple.DiskArbitration (2.7 - 2.7) <0146DA58-84E5-38CD-817A-7FCCED6DBEBB> /System/Library/Frameworks/DiskArbitration.framework/Versions/A/DiskArbitration 0x95285000 - 0x95605fff com.apple.Foundation (6.9 - 1560.12) /System/Library/Frameworks/Foundation.framework/Versions/C/Foundation 0x95646000 - 0x95675ff7 com.apple.GSS (4.0 - 2.0) <4AA2FAEA-0652-3FCF-A9C5-CE888E2D531A> /System/Library/Frameworks/GSS.framework/Versions/A/GSS 0x956a3000 - 0x957c1ffb com.apple.Bluetooth (6.0.9 - 6.0.9f2) <67CC5E9A-3B64-3DC3-BC33-16A5723C91EA> /System/Library/Frameworks/IOBluetooth.framework/Versions/A/IOBluetooth 0x9582a000 - 0x958c2ffb com.apple.framework.IOKit (2.0.2 - 1483.220.15) <8B012C27-97CC-376F-B417-75DA43E0925F> /System/Library/Frameworks/IOKit.framework/Versions/A/IOKit 0x958c4000 - 0x958ceffb com.apple.IOSurface (255.1 - 255.1) <47694A7C-1048-3C14-BF0C-CBA6E5C0EAF0> /System/Library/Frameworks/IOSurface.framework/Versions/A/IOSurface 0x95924000 - 0x95abcffb com.apple.ImageIO.framework (3.3.0 - 1821.6.4.1) /System/Library/Frameworks/ImageIO.framework/Versions/A/ImageIO 0x95abd000 - 0x95ac1ff3 libGIF.dylib (1821.6.4.1) <161E44C4-86F4-35CD-96BE-C7C0167B48E5> /System/Library/Frameworks/ImageIO.framework/Versions/A/Resources/libGIF.dylib 0x95ac2000 - 0x95bb1fff libJP2.dylib (1821.6.4.1) <19E4C09B-0A6E-32AA-9319-AB528F3F63B1> /System/Library/Frameworks/ImageIO.framework/Versions/A/Resources/libJP2.dylib 0x95bb2000 - 0x95bd7fff libJPEG.dylib (1821.6.4.1) /System/Library/Frameworks/ImageIO.framework/Versions/A/Resources/libJPEG.dylib 0x95bd8000 - 0x95bfefff libPng.dylib (1821.6.4.1) /System/Library/Frameworks/ImageIO.framework/Versions/A/Resources/libPng.dylib 0x95bff000 - 0x95c01ff7 libRadiance.dylib (1821.6.4.1) <30702589-856D-3980-9EDD-4B51A33888F1> /System/Library/Frameworks/ImageIO.framework/Versions/A/Resources/libRadiance.dylib 0x95c02000 - 0x95c4dfff libTIFF.dylib (1821.6.4.1) /System/Library/Frameworks/ImageIO.framework/Versions/A/Resources/libTIFF.dylib 0x9661d000 - 0x96636fff com.apple.Kerberos (3.0 - 1) <6CE793F9-BF48-33B0-BBE0-F71845F1BD40> /System/Library/Frameworks/Kerberos.framework/Versions/A/Kerberos 0x96d69000 - 0x96df4ff3 com.apple.Metal (157.60 - 157.60) /System/Library/Frameworks/Metal.framework/Versions/A/Metal 0x96df6000 - 0x96e02fff com.apple.NetFS (6.0 - 4.0) <7D32E85E-7DDB-3788-9DCD-C32006252D5D> /System/Library/Frameworks/NetFS.framework/Versions/A/NetFS 0x96e3d000 - 0x96e64ffb com.apple.audio.OpenAL (1.8 - 1.8) /System/Library/Frameworks/OpenAL.framework/Versions/A/OpenAL 0x988e8000 - 0x988f0ff3 libcldcpuengine.dylib (2.10.3) <269A8A2E-7283-3A3A-B8A4-3CB1FCF02656> /System/Library/Frameworks/OpenCL.framework/Versions/A/Libraries/libcldcpuengine.dylib 0x988f1000 - 0x98947fff com.apple.opencl (2.12.7 - 2.12.7) <739DA509-930D-3993-9ED6-998BADFE1578> /System/Library/Frameworks/OpenCL.framework/Versions/A/OpenCL 0x98948000 - 0x98964fff com.apple.CFOpenDirectory (10.14 - 207.200.4) /System/Library/Frameworks/OpenDirectory.framework/Versions/A/Frameworks/CFOpenDirectory.framework/Versions/A/CFOpenDirectory 0x98965000 - 0x98970ffb com.apple.OpenDirectory (10.14 - 207.200.4) <17409D7F-7F79-3F77-8493-E53ADC2F942D> /System/Library/Frameworks/OpenDirectory.framework/Versions/A/OpenDirectory 0x992f2000 - 0x992f4fff libCVMSPluginSupport.dylib (17.0.37) /System/Library/Frameworks/OpenGL.framework/Versions/A/Libraries/libCVMSPluginSupport.dylib 0x992f5000 - 0x992f9fff libCoreFSCache.dylib (163.20) <73CDB0ED-E603-3342-B8BE-A0FA59674D36> /System/Library/Frameworks/OpenGL.framework/Versions/A/Libraries/libCoreFSCache.dylib 0x992fa000 - 0x992fefff libCoreVMClient.dylib (163.20) <34792307-E66B-3CFB-836A-4E544701668D> /System/Library/Frameworks/OpenGL.framework/Versions/A/Libraries/libCoreVMClient.dylib 0x992ff000 - 0x99307ff3 libGFXShared.dylib (17.0.37) <32A3E5D3-5A86-30E3-A621-848571B965D2> /System/Library/Frameworks/OpenGL.framework/Versions/A/Libraries/libGFXShared.dylib 0x99308000 - 0x99314fff libGL.dylib (17.0.37) /System/Library/Frameworks/OpenGL.framework/Versions/A/Libraries/libGL.dylib 0x99315000 - 0x9934ffeb libGLImage.dylib (17.0.37) /System/Library/Frameworks/OpenGL.framework/Versions/A/Libraries/libGLImage.dylib 0x99350000 - 0x994d0ffb libGLProgrammability.dylib (17.0.37) /System/Library/Frameworks/OpenGL.framework/Versions/A/Libraries/libGLProgrammability.dylib 0x994d1000 - 0x9950fff7 libGLU.dylib (17.0.37) <48FCB928-BC2D-3D1A-AAF7-5681727062FB> /System/Library/Frameworks/OpenGL.framework/Versions/A/Libraries/libGLU.dylib 0x99ee0000 - 0x99eefffb com.apple.opengl (17.0.37 - 17.0.37) /System/Library/Frameworks/OpenGL.framework/Versions/A/OpenGL 0x99ef0000 - 0x99f1aff3 GLRendererFloat (17.0.37) <2E63C1E8-3CCB-338C-A376-D762AD36DA4B> /System/Library/Frameworks/OpenGL.framework/Versions/A/Resources/GLRendererFloat.bundle/GLRendererFloat 0x9aa03000 - 0x9ac4afff com.apple.QuartzCore (1.11 - 694.22.4.1) <590427B7-A591-381B-9C50-21BB468750E6> /System/Library/Frameworks/QuartzCore.framework/Versions/A/QuartzCore 0x9b0e4000 - 0x9b3f7ff7 com.apple.security (7.0 - 58286.220.15) /System/Library/Frameworks/Security.framework/Versions/A/Security 0x9b3f8000 - 0x9b46affb com.apple.securityfoundation (6.0 - 55185.200.14) <8DBE66C0-F75F-3A41-A3FB-1BF9FF91CB48> /System/Library/Frameworks/SecurityFoundation.framework/Versions/A/SecurityFoundation 0x9b493000 - 0x9b497ffb com.apple.xpc.ServiceManagement (1.0 - 1) <6DF9EEA9-BD41-3ECA-AB6A-0123116A70BD> /System/Library/Frameworks/ServiceManagement.framework/Versions/A/ServiceManagement 0x9b5cb000 - 0x9b63bfff com.apple.SystemConfiguration (1.17 - 1.17) <25649289-0A96-39F0-8A19-0D4A73F4E88C> /System/Library/Frameworks/SystemConfiguration.framework/Versions/A/SystemConfiguration 0x9d937000 - 0x9d9ecff7 com.apple.APFS (1.0 - 1) <61BDE52D-378D-329F-8236-31DD2E9BFF52> /System/Library/PrivateFrameworks/APFS.framework/Versions/A/APFS 0x9e12c000 - 0x9e15bffb com.apple.framework.Apple80211 (13.0 - 1376.2) <9383667A-BB47-36CB-8C18-D51082BA4302> /System/Library/PrivateFrameworks/Apple80211.framework/Versions/A/Apple80211 0x9e15d000 - 0x9e167ffb com.apple.AppleFSCompression (96.200.3 - 1.0) /System/Library/PrivateFrameworks/AppleFSCompression.framework/Versions/A/AppleFSCompression 0x9e267000 - 0x9e2a5ff7 com.apple.AppleJPEG (1.0 - 1) /System/Library/PrivateFrameworks/AppleJPEG.framework/Versions/A/AppleJPEG 0x9e3f7000 - 0x9e400fff com.apple.coreservices.BackgroundTaskManagement (1.0 - 57.1) /System/Library/PrivateFrameworks/BackgroundTaskManagement.framework/Versions/A/BackgroundTaskManagement 0x9e401000 - 0x9e4a6ff3 com.apple.backup.framework (1.10 - ???) <3894CB14-6619-33F1-BF5A-40A2D72014EA> /System/Library/PrivateFrameworks/Backup.framework/Versions/A/Backup 0x9e5eb000 - 0x9e5f4ff7 com.apple.CommonAuth (4.0 - 2.0) /System/Library/PrivateFrameworks/CommonAuth.framework/Versions/A/CommonAuth 0x9ea72000 - 0x9ea85fff com.apple.CoreEmoji (1.0 - 69.19.8) /System/Library/PrivateFrameworks/CoreEmoji.framework/Versions/A/CoreEmoji 0x9eaf3000 - 0x9eb66ff7 com.apple.CoreNLP (1.0 - 130.15.22) /System/Library/PrivateFrameworks/CoreNLP.framework/Versions/A/CoreNLP 0x9ec12000 - 0x9ec44ffb com.apple.CoreServicesInternal (357 - 357) <007C2DA7-D0D5-3518-9EEB-1C6AD3329A5A> /System/Library/PrivateFrameworks/CoreServicesInternal.framework/Versions/A/CoreServicesInternal 0x9ec45000 - 0x9ecd7ff3 com.apple.CoreSymbolication (10.1 - 64460.6) <061956E0-FCC8-3E30-A223-1D9E04BC7BAC> /System/Library/PrivateFrameworks/CoreSymbolication.framework/Versions/A/CoreSymbolication 0x9ecd8000 - 0x9edfcffb com.apple.coreui (2.1 - 498.46) /System/Library/PrivateFrameworks/CoreUI.framework/Versions/A/CoreUI 0x9edfd000 - 0x9eed1fff com.apple.CoreUtils (5.7.4 - 574.17) /System/Library/PrivateFrameworks/CoreUtils.framework/Versions/A/CoreUtils 0x9ef24000 - 0x9ef81ffb com.apple.framework.CoreWiFi (13.0 - 1370.8) /System/Library/PrivateFrameworks/CoreWiFi.framework/Versions/A/CoreWiFi 0x9ef82000 - 0x9ef93fff com.apple.CrashReporterSupport (10.13 - 938.23) /System/Library/PrivateFrameworks/CrashReporterSupport.framework/Versions/A/CrashReporterSupport 0x9f001000 - 0x9f00effb com.apple.framework.DFRFoundation (1.0 - 211) /System/Library/PrivateFrameworks/DFRFoundation.framework/Versions/A/DFRFoundation 0x9f052000 - 0x9f0c2ffb com.apple.datadetectorscore (7.0 - 590.24) <7BFD3A55-B3F5-3D72-8283-6C96E3B3A0A4> /System/Library/PrivateFrameworks/DataDetectorsCore.framework/Versions/A/DataDetectorsCore 0x9f0c3000 - 0x9f104ff3 com.apple.DebugSymbols (185 - 185) /System/Library/PrivateFrameworks/DebugSymbols.framework/Versions/A/DebugSymbols 0x9f105000 - 0x9f266ff7 com.apple.desktopservices (1.13.1 - ???) /System/Library/PrivateFrameworks/DesktopServicesPriv.framework/Versions/A/DesktopServicesPriv 0x9f577000 - 0x9f9a1ff7 com.apple.vision.FaceCore (3.3.4 - 3.3.4) /System/Library/PrivateFrameworks/FaceCore.framework/Versions/A/FaceCore 0xa2846000 - 0xa2851ffb libGPUSupportMercury.dylib (17.0.37) <3F3D2781-855A-3470-BAD7-F709FA3D9F67> /System/Library/PrivateFrameworks/GPUSupport.framework/Versions/A/Libraries/libGPUSupportMercury.dylib 0xa3547000 - 0xa35bbfff com.apple.Heimdal (4.0 - 2.0) /System/Library/PrivateFrameworks/Heimdal.framework/Versions/A/Heimdal 0xa3893000 - 0xa389affb com.apple.IOAccelerator (400.27 - 400.27) <51398910-F476-39FD-84B8-FF362EA79E6B> /System/Library/PrivateFrameworks/IOAccelerator.framework/Versions/A/IOAccelerator 0xa389b000 - 0xa38b5fff com.apple.IOPresentment (1.0 - 42.6) /System/Library/PrivateFrameworks/IOPresentment.framework/Versions/A/IOPresentment 0xa3911000 - 0xa393affb com.apple.IconServices (379 - 379) <7ED72945-CE7E-370A-844C-22F318A47F6C> /System/Library/PrivateFrameworks/IconServices.framework/Versions/A/IconServices 0xa396f000 - 0xa3a64ff3 com.apple.LanguageModeling (1.0 - 159.15.15) <4A54301F-E641-3718-823C-BA3F27829A93> /System/Library/PrivateFrameworks/LanguageModeling.framework/Versions/A/LanguageModeling 0xa3a65000 - 0xa3aa5fff com.apple.Lexicon-framework (1.0 - 33.15.10) <5A8FF68F-2910-3339-AE91-FD9502690B9A> /System/Library/PrivateFrameworks/Lexicon.framework/Versions/A/Lexicon 0xa3aa9000 - 0xa3aafffb com.apple.LinguisticData (1.0 - 238.15.29) <5A572187-C786-3625-9598-539C4E883339> /System/Library/PrivateFrameworks/LinguisticData.framework/Versions/A/LinguisticData 0xa3c62000 - 0xa3c88ff3 com.apple.spotlight.metadata.utilities (1.0 - 1191.52) <88819CD0-1FBD-3DE6-9DEC-8076E17807C8> /System/Library/PrivateFrameworks/MetadataUtilities.framework/Versions/A/MetadataUtilities 0xa3e90000 - 0xa3ebbff7 com.apple.MultitouchSupport.framework (2410.5 - 2410.5) <1283B2FF-0403-3CA8-8DB1-41338B25BB37> /System/Library/PrivateFrameworks/MultitouchSupport.framework/Versions/A/MultitouchSupport 0xa3fbc000 - 0xa3fc7fff com.apple.NetAuth (6.2 - 6.2) /System/Library/PrivateFrameworks/NetAuth.framework/Versions/A/NetAuth 0xa4023000 - 0xa4078ff3 com.apple.OTSVG (1.0 - ???) <10BE1531-65A0-362C-BE4C-A6DD748FF439> /System/Library/PrivateFrameworks/OTSVG.framework/Versions/A/OTSVG 0xa40c6000 - 0xa40d3ff7 com.apple.PerformanceAnalysis (1.217 - 217) /System/Library/PrivateFrameworks/PerformanceAnalysis.framework/Versions/A/PerformanceAnalysis 0xa416c000 - 0xa4188ff7 com.apple.ProtocolBuffer (1 - 263) <2F48288B-BF75-3978-8D58-6F2CCAEBD3F9> /System/Library/PrivateFrameworks/ProtocolBuffer.framework/Versions/A/ProtocolBuffer 0xa4274000 - 0xa4296fff com.apple.RemoteViewServices (2.0 - 128) <467D0451-4F47-31BC-802C-506D12825857> /System/Library/PrivateFrameworks/RemoteViewServices.framework/Versions/A/RemoteViewServices 0xa4341000 - 0xa435dff7 com.apple.Sharing (1214.9 - 1214.9) /System/Library/PrivateFrameworks/Sharing.framework/Versions/A/Sharing 0xa437d000 - 0xa4407ff3 com.apple.SkyLight (1.600.0 - 336.81.5) <4173E475-159D-33CE-BA7C-6A3E2FA2C369> /System/Library/PrivateFrameworks/SkyLight.framework/Versions/A/SkyLight 0xa4437000 - 0xa4444fff com.apple.SpeechRecognitionCore (5.0.21 - 5.0.21) <35E1860A-D570-352B-90BC-EE8C1DCD3896> /System/Library/PrivateFrameworks/SpeechRecognitionCore.framework/Versions/A/SpeechRecognitionCore 0xa4746000 - 0xa47d1ff3 com.apple.Symbolication (10.1 - 64460.8) <5E9AAA68-1FDB-39D5-91E5-EFA06E3B30C5> /System/Library/PrivateFrameworks/Symbolication.framework/Versions/A/Symbolication 0xa4825000 - 0xa4832fff com.apple.TCC (1.0 - 1) <688BC0E1-0317-3098-B4C9-0B4ACF98CD1E> /System/Library/PrivateFrameworks/TCC.framework/Versions/A/TCC 0xa4833000 - 0xa484affb com.apple.TextureIO (3.8.4 - 3.8.1) <47E8A9FD-00C6-3BEC-9529-C38DE18E764B> /System/Library/PrivateFrameworks/TextureIO.framework/Versions/A/TextureIO 0xa487a000 - 0xa487bff7 com.apple.TrustEvaluationAgent (2.0 - 31.200.1) <5A66CA46-B1DF-3AE7-9322-DCEFBCC5ECC8> /System/Library/PrivateFrameworks/TrustEvaluationAgent.framework/Versions/A/TrustEvaluationAgent 0xa487c000 - 0xa4a04ff3 com.apple.UIFoundation (1.0 - 551) /System/Library/PrivateFrameworks/UIFoundation.framework/Versions/A/UIFoundation 0xa4cb1000 - 0xa4d8ffff com.apple.ViewBridge (401.1 - 401.1) <83B99E89-AA4F-3908-88D1-C01A5FC75D0C> /System/Library/PrivateFrameworks/ViewBridge.framework/Versions/A/ViewBridge 0xa4f06000 - 0xa4f08fff com.apple.loginsupport (1.0 - 1) /System/Library/PrivateFrameworks/login.framework/Versions/A/Frameworks/loginsupport.framework/Versions/A/loginsupport 0xa4f09000 - 0xa4f1afff com.apple.login (3.0 - 3.0) /System/Library/PrivateFrameworks/login.framework/Versions/A/login 0xa5002000 - 0xa5038ff3 libCRFSuite.dylib (41.15.4) <9F58B957-D463-3F34-920C-EDAD6B974CA6> /usr/lib/libCRFSuite.dylib 0xa5039000 - 0xa5043fff libChineseTokenizer.dylib (28.15.3) /usr/lib/libChineseTokenizer.dylib 0xa50dd000 - 0xa50defff libDiagnosticMessagesClient.dylib (107) /usr/lib/libDiagnosticMessagesClient.dylib 0xa5110000 - 0xa52effff libFosl_dynamic.dylib (18.3.2) <8BD9F045-35DE-3DF4-BDBD-4249477B7518> /usr/lib/libFosl_dynamic.dylib 0xa52f7000 - 0xa52f7fff libOpenScriptingUtil.dylib (179) <20609A86-C272-3C1D-8113-F2EDBD7E9FFF> /usr/lib/libOpenScriptingUtil.dylib 0xa5433000 - 0xa5434ffb libSystem.B.dylib (1252.200.5) <9B4EC833-9228-3918-B04B-0778EAFA40AB> /usr/lib/libSystem.B.dylib 0xa5435000 - 0xa5436ffb libThaiTokenizer.dylib (2.15.1) <1D99E78B-27CE-3364-9867-142CA5BFF0D8> /usr/lib/libThaiTokenizer.dylib 0xa5443000 - 0xa5459ff3 libapple_nghttp2.dylib (1.24.1) <54130CCB-854D-3991-B4B7-6E8D256D730A> /usr/lib/libapple_nghttp2.dylib 0xa545a000 - 0xa5485ffb libarchive.2.dylib (54.200.3) <403A8315-E18C-3FEA-A35E-E9E81BCA9780> /usr/lib/libarchive.2.dylib 0xa5486000 - 0xa55d0fef libate.dylib (1.13.8) /usr/lib/libate.dylib 0xa55d4000 - 0xa55d4ff3 libauto.dylib (187) /usr/lib/libauto.dylib 0xa55d5000 - 0xa55e5fff libbsm.0.dylib (39.200.18) <945EC822-9C15-393B-9570-C2143661A840> /usr/lib/libbsm.0.dylib 0xa55e6000 - 0xa55f3ff3 libbz2.1.0.dylib (38.200.3) <307735EB-63BD-3DDA-8BEE-F7D4618E1C03> /usr/lib/libbz2.1.0.dylib 0xa55f4000 - 0xa564dff7 libc++.1.dylib (400.9.4) <7D02B34A-D9AE-36D1-A4DB-D33312BBEFAB> /usr/lib/libc++.1.dylib 0xa564e000 - 0xa5661ffb libc++abi.dylib (400.17) /usr/lib/libc++abi.dylib 0xa5662000 - 0xa5662fff libcharset.1.dylib (51.200.6) <4DD7F3EA-1DA8-344C-B35F-51ED4B548423> /usr/lib/libcharset.1.dylib 0xa5663000 - 0xa5674ff3 libcmph.dylib (6.15.1) <85F62EF8-F0A3-3A40-BA01-152BFD36244A> /usr/lib/libcmph.dylib 0xa5675000 - 0xa568afeb libcompression.dylib (52.200.13) /usr/lib/libcompression.dylib 0xa568b000 - 0xa56a0fff libcoretls.dylib (155.220.1) <95F98DB2-DF19-3E71-9520-7F387C9D985E> /usr/lib/libcoretls.dylib 0xa56a1000 - 0xa56a2fff libcoretls_cfhelpers.dylib (155.220.1) /usr/lib/libcoretls_cfhelpers.dylib 0xa582a000 - 0xa59d4ff3 libcrypto.35.dylib (22.200.4) <1D130129-8B18-38C2-9F3C-83978717D180> /usr/lib/libcrypto.35.dylib 0xa5d4c000 - 0xa5da5ff3 libcups.2.dylib (462.9) <838CDADA-C720-332D-9862-0CE9476B4118> /usr/lib/libcups.2.dylib 0xa5ebb000 - 0xa5ebbfff libenergytrace.dylib (17.200.1) <9BE16C5B-E49F-3416-93E5-D5C88F37D747> /usr/lib/libenergytrace.dylib 0xa5ee9000 - 0xa5eedff3 libgermantok.dylib (17.15.2) <2350BE97-A650-341A-99CC-330EFA85003A> /usr/lib/libgermantok.dylib 0xa5eee000 - 0xa5ef2fff libheimdal-asn1.dylib (520.220.2) <509C256D-758D-3F25-99B3-3A10A22C8565> /usr/lib/libheimdal-asn1.dylib 0xa5f1e000 - 0xa600dff7 libiconv.2.dylib (51.200.6) <52245AF2-9F48-3926-93E9-F70D39E8D6C7> /usr/lib/libiconv.2.dylib 0xa600e000 - 0xa626bff3 libicucore.A.dylib (62108.0.1) <852AA6BF-131A-312B-9083-61E3F45D590C> /usr/lib/libicucore.A.dylib 0xa62b2000 - 0xa62b3fff liblangid.dylib (128.15.1) <1FCAB52F-AFD4-39B4-8AF3-3491EFD89993> /usr/lib/liblangid.dylib 0xa62b4000 - 0xa62ccfff liblzma.5.dylib (10.200.3) <7A9AB6A6-495F-3595-BAB5-2455AE11969A> /usr/lib/liblzma.5.dylib 0xa62e3000 - 0xa6397ff3 libmecab.1.0.0.dylib (779.19.2) /usr/lib/libmecab.1.0.0.dylib 0xa6398000 - 0xa65cdff7 libmecabra.dylib (779.19.2) <02E08BBA-F619-346E-9310-5EBCFF205AD5> /usr/lib/libmecabra.dylib 0xa6795000 - 0xa6addff7 libnetwork.dylib (1229.221.1) <2FFEADA2-525B-39C9-A21F-CF59102AFC22> /usr/lib/libnetwork.dylib 0xa6ade000 - 0xa7253ffb libobjc.A.dylib (750.1) <09652190-E142-3C03-B00F-641CC6C5D704> /usr/lib/libobjc.A.dylib 0xa7257000 - 0xa725bfff libpam.2.dylib (22.200.1) <4B96D846-A31C-3714-9150-494F84C2E682> /usr/lib/libpam.2.dylib 0xa725e000 - 0xa7293ff3 libpcap.A.dylib (79.200.4) <86677AC6-239B-3076-A078-3663D067AF67> /usr/lib/libpcap.A.dylib 0xa72d1000 - 0xa72e9ff7 libresolv.9.dylib (65.200.2) <92AD828A-C7A1-32C8-9774-106D7A518E5E> /usr/lib/libresolv.9.dylib 0xa7338000 - 0xa7501fff libsqlite3.dylib (274.20) <18AFAC11-D0E1-3746-906F-3A3FFF988C6E> /usr/lib/libsqlite3.dylib 0xa7764000 - 0xa7767ffb libutil.dylib (51.200.4) <68F84D39-FAB3-32B5-9424-5D6BC485BFF7> /usr/lib/libutil.dylib 0xa7768000 - 0xa7775ffb libxar.1.dylib (404) <6198D1EE-5DCB-3725-BAA0-8A9630968C6F> /usr/lib/libxar.1.dylib 0xa7776000 - 0xa7855ffb libxml2.2.dylib (32.8) /usr/lib/libxml2.2.dylib 0xa7856000 - 0xa787eff3 libxslt.1.dylib (16.1) <35263404-4E56-3D28-9420-D244F0DCB29F> /usr/lib/libxslt.1.dylib 0xa787f000 - 0xa788efff libz.1.dylib (70.200.4) <3A38FE91-88BA-3C0B-A2C0-FEC852AAE542> /usr/lib/libz.1.dylib 0xa78c8000 - 0xa78ccfff libcache.dylib (81) <0E1883DB-51FE-3426-BD54-C201B9B67251> /usr/lib/system/libcache.dylib 0xa78cd000 - 0xa78d7fff libcommonCrypto.dylib (60118.220.1) <8A60F9D2-57C4-30CE-8DD9-901A3B74E0F9> /usr/lib/system/libcommonCrypto.dylib 0xa78d8000 - 0xa78dffff libcompiler_rt.dylib (63.4) <44CD2149-88F4-3A60-85BE-C9BA3C4CB33C> /usr/lib/system/libcompiler_rt.dylib 0xa78e0000 - 0xa78eafff libcopyfile.dylib (146.200.3) <5BE00D0E-BF42-35B3-B8CB-C84ABFDD7E57> /usr/lib/system/libcopyfile.dylib 0xa78eb000 - 0xa7952ffb libcorecrypto.dylib (602.220.6) <7A457D0C-18BD-33CA-A7BD-BC7067BF12BA> /usr/lib/system/libcorecrypto.dylib 0xa79bc000 - 0xa79f3ff3 libdispatch.dylib (1008.220.2) <77F2627A-0C5E-39CE-BB45-A78F3F4D001A> /usr/lib/system/libdispatch.dylib 0xa79f4000 - 0xa7a23fff libdyld.dylib (635.2) /usr/lib/system/libdyld.dylib 0xa7a24000 - 0xa7a24ffb libkeymgr.dylib (30) /usr/lib/system/libkeymgr.dylib 0xa7a25000 - 0xa7a31ff3 libkxld.dylib (4903.221.2) <12A4DC73-3F0A-3053-BEF9-BFC35C8EC87A> /usr/lib/system/libkxld.dylib 0xa7a32000 - 0xa7a32fff liblaunch.dylib (1336.220.5) <5A89FAD6-006B-31FF-BE5C-BCF6D0877854> /usr/lib/system/liblaunch.dylib 0xa7a33000 - 0xa7a38ff3 libmacho.dylib (921) <16AEFD80-AFAC-348B-BE74-1DD5F1EC22DF> /usr/lib/system/libmacho.dylib 0xa7a39000 - 0xa7a3bffb libquarantine.dylib (86.220.1) <7CFE1933-38C2-3839-B76D-6A54CB452D4D> /usr/lib/system/libquarantine.dylib 0xa7a3c000 - 0xa7a3dffb libremovefile.dylib (45.200.2) <0883CD67-69ED-3A84-ACBC-6354EE5A61F3> /usr/lib/system/libremovefile.dylib 0xa7a3e000 - 0xa7a55fff libsystem_asl.dylib (356.200.4) <5548F4FF-DFB9-34C8-9430-069816762645> /usr/lib/system/libsystem_asl.dylib 0xa7a56000 - 0xa7a56fff libsystem_blocks.dylib (73) /usr/lib/system/libsystem_blocks.dylib 0xa7a57000 - 0xa7ae3ff3 libsystem_c.dylib (1272.200.26) /usr/lib/system/libsystem_c.dylib 0xa7ae4000 - 0xa7ae7fff libsystem_configuration.dylib (963.200.27) <38F3942B-E770-3C7B-B457-829670B7D074> /usr/lib/system/libsystem_configuration.dylib 0xa7ae8000 - 0xa7aebfff libsystem_coreservices.dylib (66) /usr/lib/system/libsystem_coreservices.dylib 0xa7aec000 - 0xa7af1fff libsystem_darwin.dylib (1272.200.26) <85288DAB-860D-3DA8-898B-D8DF56142E3D> /usr/lib/system/libsystem_darwin.dylib 0xa7af2000 - 0xa7af8ffb libsystem_dnssd.dylib (878.200.35) /usr/lib/system/libsystem_dnssd.dylib 0xa7af9000 - 0xa7b4bff7 libsystem_info.dylib (517.200.9) <4AA8F291-4901-33A3-A148-1FBFFF01597A> /usr/lib/system/libsystem_info.dylib 0xa7b4c000 - 0xa7b73ff7 libsystem_kernel.dylib (4903.221.2) <18DEEB60-1DBD-3CD2-BCB2-481CAE013562> /usr/lib/system/libsystem_kernel.dylib 0xa7b74000 - 0xa7bc2fdb libsystem_m.dylib (3158.200.7) <90830E34-355E-3B80-94AF-2799DE1B2960> /usr/lib/system/libsystem_m.dylib 0xa7bc3000 - 0xa7bdffff libsystem_malloc.dylib (166.220.1) /usr/lib/system/libsystem_malloc.dylib 0xa7be0000 - 0xa7bebfff libsystem_networkextension.dylib (767.220.1) <23B154B9-AD7D-37E9-8611-A141808BFEB1> /usr/lib/system/libsystem_networkextension.dylib 0xa7bec000 - 0xa7bf2fff libsystem_notify.dylib (172.200.21) /usr/lib/system/libsystem_notify.dylib 0xa7bf3000 - 0xa7bfaffb libsystem_platform.dylib (177.200.16) <845B96BC-6B5F-32CB-A229-294BD5771435> /usr/lib/system/libsystem_platform.dylib 0xa7bfb000 - 0xa7c06ffb libsystem_pthread.dylib (330.220.2) <647CA068-5F50-3542-B101-C2F7CE3BA473> /usr/lib/system/libsystem_pthread.dylib 0xa7c07000 - 0xa7c0aff7 libsystem_sandbox.dylib (851.220.9) <5F124AC2-E305-3A26-A863-B4D0183792CC> /usr/lib/system/libsystem_sandbox.dylib 0xa7c0b000 - 0xa7c0dfff libsystem_secinit.dylib (30.220.1) <8BC61243-2315-3FA9-BC08-5B698020B293> /usr/lib/system/libsystem_secinit.dylib 0xa7c0e000 - 0xa7c15fff libsystem_symptoms.dylib (820.227.2) /usr/lib/system/libsystem_symptoms.dylib 0xa7c16000 - 0xa7c2affb libsystem_trace.dylib (906.220.1) /usr/lib/system/libsystem_trace.dylib 0xa7c2c000 - 0xa7c32fff libunwind.dylib (35.4) /usr/lib/system/libunwind.dylib 0xa7c33000 - 0xa7c62ffb libxpc.dylib (1336.220.5) <69B954DC-F4FC-3FBC-B7DC-E9CC9FE898F3> /usr/lib/system/libxpc.dylib

External Modification Summary:
Calls made by other processes targeting this process:
task_for_pid: 3
thread_create: 0
thread_set_state: 0
Calls made by this process:
task_for_pid: 0
thread_create: 0
thread_set_state: 0
Calls made by all processes on this machine:
task_for_pid: 15350
thread_create: 0
thread_set_state: 0

VM Region Summary:
ReadOnly portion of Libraries: Total=391.6M resident=0K(0%) swapped_out_or_unallocated=391.6M(100%)
Writable regions: Total=661.9M written=0K(0%) resident=0K(0%) swapped_out=0K(0%) unallocated=661.9M(100%)

                            VIRTUAL   REGION  REGION TYPE                        SIZE    COUNT (non-coalesced)  ===========                     =======  =======  Accelerate framework               128K        2  Activity Tracing                   256K        2  CG backing stores                 5536K        4  CG image                            12K        3  CoreAnimation                      124K       14  CoreGraphics                         8K        2  CoreImage                           16K        3  CoreUI image data                  296K        6  CoreUI image file                  404K        5  Foundation                           4K        2  Kernel Alloc Once                    8K        2  MALLOC                           610.9M      102  MALLOC guard page                   32K        9  Memory Tag 242                      12K        2  Memory Tag 249                     156K        2  OpenGL GLSL                        128K        3  Stack                             19.4M       16  Stack (reserved)                  24.0M        2         reserved VM address space (unallocated) Stack Guard                       32.0M       14  VM_ALLOCATE                        296K       25  VM_ALLOCATE (reserved)              36K        2         reserved VM address space (unallocated) __DATA                            17.7M      229  __FONT_DATA                          4K        2  __GLSLBUILTINS                    5176K        2  __LINKEDIT                       150.7M       12  __OBJC                            3188K       81  __TEXT                           240.8M      231  __UNICODE                          564K        2  mapped file                      329.0M      216  shared memory                      752K       12  ===========                     =======  =======  TOTAL                              1.4G      979  TOTAL, minus reserved VM space     1.4G      979

Model: MacBookPro11,3, BootROM 149.0.0.0.0, 4 processors, Intel Core i7, 2.6 GHz, 16 GB, SMC 2.19f12
Graphics: Intel Iris Pro, Intel Iris Pro, Built-In
Graphics: NVIDIA GeForce GT 750M, NVIDIA GeForce GT 750M, PCIe
Memory Module: BANK 0/DIMM0, 8 GB, DDR3, 1600 MHz, 0x80AD, 0x484D54343147533641465238412D50422020
Memory Module: BANK 1/DIMM0, 8 GB, DDR3, 1600 MHz, 0x80AD, 0x484D54343147533641465238412D50422020
AirPort: spairport_wireless_card_type_airport_extreme (0x14E4, 0x134), Broadcom BCM43xx 1.0 (7.77.61.1 AirPortDriverBrcmNIC-1305.2)
Bluetooth: Version 6.0.9f2, 3 services, 27 devices, 1 incoming serial ports
Network Service: AirPort, AirPort, en0
Serial ATA Device: APPLE SSD SM1024G, 1 TB
USB Device: USB 3.0 Bus
USB Device: Apple Internal Keyboard / Trackpad
USB Device: BRCM20702 Hub
USB Device: Bluetooth USB Host Controller
Thunderbolt Bus: MacBook Pro, Apple Inc., 17.1