Foldit

1600: Symmetric Dimer Design

Closed since over 7 years ago

Summary

Created: November 15, 2018
Expires: November 22, 2018 at 23:00 UTC
Max points: 100

Description

This symmetric design puzzle has C2 symmetry, with two symmetric chains. There is no H-bond Network Objective in this puzzle, so the interface can be completely nonpolar (orange sidechains). However, solutions may have no more than 50% of residues in helices. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

11. Deleted group pts. 11,492
12. Trinity Biology 1 pt. 10,443
13. freefolder 1 pt. 9,572
14. Team South Africa 1 pt. 0
15. FoldIt@Netherlands 1 pt. 0
16. DSN @ Home 1 pt. 0
17. Window Group 1 pt. 0

31. uihcv Lv 1 20 pts. 19,047
32. isaksson Lv 1 19 pts. 19,040
33. jamiexq Lv 1 18 pts. 18,926
34. robgee Lv 1 17 pts. 18,818
35. christioanchauvin Lv 1 16 pts. 18,770
36. Wojcimierz Lv 1 15 pts. 18,507
37. vakobo Lv 1 14 pts. 18,496
38. smilingone Lv 1 13 pts. 18,400
39. Maerlyn138 Lv 1 12 pts. 18,176
40. Deleted player pts. 18,051

Comments

bkoep Staff Lv 1

November 15, 2018

Core Existence: Monomer (max +1900)
Ensures that at least 19 residues are buried in the core of the monomer unit.

Core Existence: Complex (max +2400)
Ensures that at least 48 residues are buried in the core of the entire complex (including the interface between monomer units).

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets and helices

Secondary Structure (max +500)
No more than 50% of residues may form helices. Extra helices are penalized at 10 points per residue.