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1600: Symmetric Dimer Design

Closed since over 7 years ago

Intermediate Overall Design

Summary

Created
November 15, 2018
Expires
Max points
100
Description

This symmetric design puzzle has C2 symmetry, with two symmetric chains. There is no H-bond Network Objective in this puzzle, so the interface can be completely nonpolar (orange sidechains). However, solutions may have no more than 50% of residues in helices. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

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  2. Avatar for Trinity Biology 12. Trinity Biology 1 pt. 10,443
  3. Avatar for freefolder 13. freefolder 1 pt. 9,572
  4. Avatar for Team South Africa 14. Team South Africa 1 pt. 0
  5. Avatar for FoldIt@Netherlands 15. FoldIt@Netherlands 1 pt. 0
  6. Avatar for DSN @ Home 16. DSN @ Home 1 pt. 0
  7. Avatar for Window Group 17. Window Group 1 pt. 0
  1. Avatar for Incongruous 71. Incongruous Lv 1 1 pt. 14,756
  2. Avatar for dd-2 72. dd-2 Lv 1 1 pt. 14,359
  3. Avatar for fisherlr777 73. fisherlr777 Lv 1 1 pt. 14,349
  4. Avatar for kludbrook 74. kludbrook Lv 1 1 pt. 13,803
  5. Avatar for Phyx 75. Phyx Lv 1 1 pt. 13,248
  6. Avatar for pfirth 76. pfirth Lv 1 1 pt. 13,028
  7. Avatar for mitarcher 77. mitarcher Lv 1 1 pt. 12,292
  8. Avatar for Anamfija 78. Anamfija Lv 1 1 pt. 12,043
  9. Avatar for rezaefar 79. rezaefar Lv 1 1 pt. 11,815
  10. Avatar for freethought78 80. freethought78 Lv 1 1 pt. 11,492

Comments

bkoep Staff Lv 1

Core Existence: Monomer (max +1900)
Ensures that at least 19 residues are buried in the core of the monomer unit.

Core Existence: Complex (max +2400)
Ensures that at least 48 residues are buried in the core of the entire complex (including the interface between monomer units).

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets and helices

Secondary Structure (max +500)
No more than 50% of residues may form helices. Extra helices are penalized at 10 points per residue.