Placeholder image of a protein
Icon representing a puzzle

1605: Symmetric Dimer Design

Closed since over 7 years ago

Intermediate Overall Design Symmetry

Summary

Created
November 30, 2018
Expires
Max points
100
Description

This symmetric design puzzle has C2 symmetry, with two symmetric chains. There is no H-bond Network Objective in this puzzle, so the interface can be completely nonpolar (orange sidechains). There are no helix restrictions, but all loops must match one of the Ideal Loop Building Blocks found in the Blueprint tool. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Gargleblasters
    1. Gargleblasters
    100 pts. 22,689
  2. Avatar for Contenders 2. Contenders 65 pts. 22,486
  3. Avatar for Beta Folders 3. Beta Folders 41 pts. 22,316
  4. Avatar for Go Science 4. Go Science 24 pts. 22,308
  5. Avatar for Anthropic Dreams 5. Anthropic Dreams 14 pts. 22,173
  6. Avatar for Void Crushers 6. Void Crushers 7 pts. 22,013
  7. Avatar for Marvin's bunch 7. Marvin's bunch 4 pts. 21,831
  8. Avatar for L'Alliance Francophone 8. L'Alliance Francophone 2 pts. 21,190
  9. Avatar for Russian team 9. Russian team 1 pt. 20,680
  10. Avatar for Hold My Beer 10. Hold My Beer 1 pt. 17,018
  1. Avatar for tyler0911 31. tyler0911 Lv 1 20 pts. 21,193
  2. Avatar for christioanchauvin 32. christioanchauvin Lv 1 19 pts. 21,190
  3. Avatar for guineapig 33. guineapig Lv 1 18 pts. 21,111
  4. Avatar for jausmh 34. jausmh Lv 1 17 pts. 21,111
  5. Avatar for Glen B 35. Glen B Lv 1 16 pts. 21,081
  6. Avatar for Bletchley Park 36. Bletchley Park Lv 1 15 pts. 20,959
  7. Avatar for Wojcimierz 37. Wojcimierz Lv 1 14 pts. 20,907
  8. Avatar for Anfinsen_slept_here 38. Anfinsen_slept_here Lv 1 13 pts. 20,875
  9. Avatar for alwen 39. alwen Lv 1 12 pts. 20,857
  10. Avatar for fpc 40. fpc Lv 1 11 pts. 20,788

Comments

bkoep Staff Lv 1

Core Existence: Monomer (max +2300)
Ensures that at least 23 residues are buried in the core of the monomer unit.

Core Existence: Complex (max +2700)
Ensures that at least 54 residues are buried in the core of the entire complex (including the interface between monomer units).

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets and helices

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.