Placeholder image of a protein
Icon representing a puzzle

1608: Symmetric Dimer Design: Hydrogen Bond Networks

Closed since over 7 years ago

Advanced Advanced Overall Overall Design Design Symmetry Symmetry

Summary


Created
December 07, 2018
Expires
Max points
100
Description

This symmetric design puzzle has C2 symmetry, with two symmetric chains. The H-bond Network Bonus encourages players to bury H-bond networks at the interface between the two chains. We've doubled the H-bond network bonus, but we'd like players to focus on building networks deep in the core of the protein complex. There are a couple other bonuses in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups


  1. Avatar for HMT heritage 11. HMT heritage 2 pts. 16,341
  2. Avatar for Hold My Beer 12. Hold My Beer 1 pt. 15,584
  3. Avatar for Czech National Team 13. Czech National Team 1 pt. 14,696
  4. Avatar for Rechenkraft.net 14. Rechenkraft.net 1 pt. 11,625
  5. Avatar for DW 2020 15. DW 2020 1 pt. 9,658
  6. Avatar for DSN @ Home 16. DSN @ Home 1 pt. 0
  7. Avatar for OmHS 17. OmHS 1 pt. 0

  1. Avatar for jobo0502 51. jobo0502 Lv 1 7 pts. 16,836
  2. Avatar for Altercomp 52. Altercomp Lv 1 6 pts. 16,741
  3. Avatar for fpc 53. fpc Lv 1 6 pts. 16,696
  4. Avatar for alcor29 54. alcor29 Lv 1 6 pts. 16,442
  5. Avatar for O Seki To 55. O Seki To Lv 1 5 pts. 16,341
  6. Avatar for multaq 56. multaq Lv 1 5 pts. 16,052
  7. Avatar for DoctorSockrates 57. DoctorSockrates Lv 1 5 pts. 16,016
  8. Avatar for Jesse Pinkman 58. Jesse Pinkman Lv 1 4 pts. 15,651
  9. Avatar for Merf 59. Merf Lv 1 4 pts. 15,631
  10. Avatar for Steven Pletsch 60. Steven Pletsch Lv 1 4 pts. 15,584

Comments


bkoep Staff Lv 1

Core Existence: Monomer (max +1900)
Ensures that at least 19 residues are buried in the core of the monomer unit. The threshold of "buriedness" between core and surface residues is more stringent than usual, so residues may have to be "extra buried" to be counted toward the core.

Core Existence: Complex (max +2100)
Ensures that at least 42 residues are buried in the core of the entire complex (including the interface between monomer units).

HBond Network
Rewards networks that comprise at least three hydrogen bonds involving core residues. Networks must be at least 70% satisfied (i.e. 70% of all oxygens and polar hydrogens in a network must make a hydrogen bond).

SS Design (max +500)
Prohibits all CYS residues. Prohibits GLY, ALA residues in sheets and helices.

dbuske Lv 1

I cannot find the 2nd chain, then I lost the 1st chain.
Q does not work to find the 1st chain.