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1608: Symmetric Dimer Design: Hydrogen Bond Networks

Closed since over 7 years ago

Advanced Advanced Overall Overall Design Design Symmetry Symmetry

Summary

Created: December 07, 2018
Expires: December 14, 2018 at 23:00 UTC
Max points: 100

Description

This symmetric design puzzle has C2 symmetry, with two symmetric chains. The H-bond Network Bonus encourages players to bury H-bond networks at the interface between the two chains. We've doubled the H-bond network bonus, but we'd like players to focus on building networks deep in the core of the protein complex. There are a couple other bonuses in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

11. HMT heritage 2 pts. 16,341
12. Hold My Beer 1 pt. 15,584
13. Czech National Team 1 pt. 14,696
14. Rechenkraft.net 1 pt. 11,625
15. DW 2020 1 pt. 9,658
16. DSN @ Home 1 pt. 0
17. OmHS 1 pt. 0
18. BrownBiomolecular 1 pt. 0
19. FoldIt@Netherlands 1 pt. 0

81. Amphimixus Lv 1 1 pt. 11,105
82. philipfoldit Lv 1 1 pt. 10,557
83. RyeSnake Lv 1 1 pt. 10,172
84. icaru-5 Lv 1 1 pt. 10,105
85. antibot215 Lv 1 1 pt. 9,816
86. rinze Lv 1 1 pt. 9,779
87. versat82 Lv 1 1 pt. 9,669
88. SiPot2018 Lv 1 1 pt. 9,658
89. Arne Heessels Lv 1 1 pt. 9,649
90. pandapharmd Lv 1 1 pt. 9,218

Comments

bkoep Staff Lv 1

December 07, 2018

Core Existence: Monomer (max +1900)
Ensures that at least 19 residues are buried in the core of the monomer unit. The threshold of "buriedness" between core and surface residues is more stringent than usual, so residues may have to be "extra buried" to be counted toward the core.

Core Existence: Complex (max +2100)
Ensures that at least 42 residues are buried in the core of the entire complex (including the interface between monomer units).

HBond Network
Rewards networks that comprise at least three hydrogen bonds involving core residues. Networks must be at least 70% satisfied (i.e. 70% of all oxygens and polar hydrogens in a network must make a hydrogen bond).

SS Design (max +500)
Prohibits all CYS residues. Prohibits GLY, ALA residues in sheets and helices.