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1617: Symmetric Trimer Design: Hydrogen Bond Networks

Closed since over 7 years ago

Advanced Overall Design Symmetry

Summary

Created
December 27, 2018
Expires
Max points
100
Description

This symmetric design puzzle has C3 symmetry, with three symmetric chains. The H-bond Network Objective encourages players to bury H-bond Networks at the interface between the two chains. We've doubled the H-bond Network bonus, but we'd like players to focus on building networks deep in the core of the protein complex. There are a couple other bonuses in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for freefolder 11. freefolder 1 pt. 18,908
  2. Avatar for Hold My Beer 12. Hold My Beer 1 pt. 17,901
  3. Avatar for FoldIt@Poland 13. FoldIt@Poland 1 pt. 14,547
  4. Avatar for FoldIt@Netherlands 14. FoldIt@Netherlands 1 pt. 12,024
  5. Avatar for Team South Africa 15. Team South Africa 1 pt. 10,310
  6. Avatar for Kotocycle 16. Kotocycle 1 pt. 0
  7. Avatar for Dutch Power Cows 17. Dutch Power Cows 1 pt. 0
  1. Avatar for Museka 21. Museka Lv 1 45 pts. 22,219
  2. Avatar for dcrwheeler 22. dcrwheeler Lv 1 43 pts. 22,132
  3. Avatar for micheldeweerd 23. micheldeweerd Lv 1 41 pts. 22,117
  4. Avatar for vakobo 24. vakobo Lv 1 40 pts. 22,085
  5. Avatar for Skippysk8s 25. Skippysk8s Lv 1 38 pts. 22,044
  6. Avatar for Timo van der Laan 26. Timo van der Laan Lv 1 36 pts. 22,006
  7. Avatar for Bletchley Park 27. Bletchley Park Lv 1 35 pts. 21,863
  8. Avatar for phi16 28. phi16 Lv 1 33 pts. 21,767
  9. Avatar for Hellcat6 29. Hellcat6 Lv 1 31 pts. 21,752
  10. Avatar for pvc78 30. pvc78 Lv 1 30 pts. 21,742

Comments

bkoep Staff Lv 1

Core Existence: Monomer (max +2100)
Ensures that at least 21 residues are buried in the core of the monomer unit. The threshold of "buriedness" between core and surface residues is more stringent than usual, so residues may have to be "extra buried" to be counted toward the core.

Core Existence: Complex (max +3600)
Ensures that at least 72 residues are buried in the core of the entire complex (including the interface between monomer units).

HBond Network
Rewards networks that comprise at least three hydrogen bonds involving core residues. Networks must be at least 70% satisfied (i.e. 70% of all oxygens and polar hydrogens in a network must make a hydrogen bond).

SS Design (max +500)
Prohibits all CYS residues. Prohibits GLY, ALA residues in sheets and helices.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.