This symmetric design puzzle has C3 symmetry, with three symmetric chains. The H-bond Network Objective encourages players to bury H-bond Networks at the interface between the two chains. We've doubled the H-bond Network bonus, but we'd like players to focus on building networks deep in the core of the protein complex. There are a couple other bonuses in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
I'm not sure what rotation problem dbuske was describing
above. It might be similar to what I experienced in Puzzles
1499 & 1499c. It might be like what Skippysk8s encountered
last March (https://fold.it/portal/node/2004913), perhaps
also for Puzzles 1499 & 1499c.
My own experience with Puzzle 1619b is that it is very slow.
Even simple things like Restore Recent Best, scrolling thru
Chat, and Freeze/Unfreeze have been much slower than usual.
I got a Recipe to evo a teammate's solution at least. This
Recipe also ran much slower than usual. I'll probably not
try to solo on this puzzle.
I did glance at the Rama Map & Blueprint Tool in the
Original Interface when I started this puzzle. They looked
normal. I was also able to rotate two of my teammates'
solutions around to see which residues were already involved
in hydrogen bond networks. Things behaved fine in my hands,
but I think all the clients I used were old ones, like from
September 2018.
