Placeholder image of a protein
Icon representing a puzzle

1641: Large Monomer Design

Closed since about 7 years ago

Intermediate Overall Design

Summary

Created
February 25, 2019
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 85-105 residues. The starting structure has 85 residues, but more can be added at a cost of 50 points per residue. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for DSN @ Home 21. DSN @ Home 1 pt. 0
  1. Avatar for RestrictionEndoNykolease 111. RestrictionEndoNykolease Lv 1 1 pt. 8,258
  2. Avatar for cenkonur 112. cenkonur Lv 1 1 pt. 7,060
  3. Avatar for ccharles2021 113. ccharles2021 Lv 1 1 pt. 6,136
  4. Avatar for Alpha-KetoGlutarate1301 114. Alpha-KetoGlutarate1301 Lv 1 1 pt. 5,264
  5. Avatar for Science_Man 115. Science_Man Lv 1 1 pt. 4,631
  6. Avatar for simmons.c.ltcc 116. simmons.c.ltcc Lv 1 1 pt. 4,523
  7. Avatar for Dhalion 117. Dhalion Lv 1 1 pt. 4,338
  8. Avatar for NotJim99 118. NotJim99 Lv 1 1 pt. 4,062
  9. Avatar for jeff101 119. jeff101 Lv 1 1 pt. 0
  10. Avatar for fisherlr777 120. fisherlr777 Lv 1 1 pt. 0

Comments

bkoep Staff Lv 1

Residue IE Score (max +500)
Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA, SER, THR in helices. Penalizes GLY, ALA in sheets.

Residue Count (max +1000)
Penalizes extra residues inserted beyond the starting 85, at a cost of 50 points per residue. Players may use up to 105 residues in total.

Secondary Structure (max +500)
No more than 50% of residues may form helices. Extra helices are penalized at 10 points per residue.