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1641: Large Monomer Design

Closed since about 7 years ago

Intermediate Overall Design

Summary

Created
February 25, 2019
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 85-105 residues. The starting structure has 85 residues, but more can be added at a cost of 50 points per residue. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for DSN @ Home 21. DSN @ Home 1 pt. 0
  1. Avatar for pvc78 31. pvc78 Lv 1 29 pts. 13,574
  2. Avatar for guineapig 32. guineapig Lv 1 27 pts. 13,557
  3. Avatar for smilingone 33. smilingone Lv 1 26 pts. 13,552
  4. Avatar for aznarog 34. aznarog Lv 1 25 pts. 13,546
  5. Avatar for Wojcimierz 35. Wojcimierz Lv 1 24 pts. 13,544
  6. Avatar for Skippysk8s 36. Skippysk8s Lv 1 23 pts. 13,544
  7. Avatar for vakobo 37. vakobo Lv 1 21 pts. 13,544
  8. Avatar for phi16 38. phi16 Lv 1 20 pts. 13,525
  9. Avatar for Museka 39. Museka Lv 1 19 pts. 13,482
  10. Avatar for O Seki To 40. O Seki To Lv 1 18 pts. 13,470

Comments

bkoep Staff Lv 1

Residue IE Score (max +500)
Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA, SER, THR in helices. Penalizes GLY, ALA in sheets.

Residue Count (max +1000)
Penalizes extra residues inserted beyond the starting 85, at a cost of 50 points per residue. Players may use up to 105 residues in total.

Secondary Structure (max +500)
No more than 50% of residues may form helices. Extra helices are penalized at 10 points per residue.