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1641: Large Monomer Design

Closed since about 7 years ago

Intermediate Overall Design

Summary

Created
February 25, 2019
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 85-105 residues. The starting structure has 85 residues, but more can be added at a cost of 50 points per residue. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Gargleblasters
    1. Gargleblasters
    100 pts. 14,108
  2. Avatar for Anthropic Dreams 2. Anthropic Dreams 78 pts. 14,069
  3. Avatar for Beta Folders 3. Beta Folders 60 pts. 14,041
  4. Avatar for Void Crushers 4. Void Crushers 45 pts. 14,008
  5. Avatar for Go Science 5. Go Science 33 pts. 13,907
  6. Avatar for Contenders 6. Contenders 24 pts. 13,870
  7. Avatar for L'Alliance Francophone 7. L'Alliance Francophone 17 pts. 13,778
  8. Avatar for Marvin's bunch 8. Marvin's bunch 12 pts. 13,776
  9. Avatar for Russian team 9. Russian team 8 pts. 13,544
  10. Avatar for HMT heritage 10. HMT heritage 6 pts. 13,470
  1. Avatar for reefyrob 21. reefyrob Lv 1 1 pt. 13,860
  2. Avatar for georg137 22. georg137 Lv 1 1 pt. 13,834
  3. Avatar for alcor29 23. alcor29 Lv 1 1 pt. 13,832
  4. Avatar for Anfinsen_slept_here 24. Anfinsen_slept_here Lv 1 1 pt. 13,820
  5. Avatar for retiredmichael 25. retiredmichael Lv 1 1 pt. 13,816
  6. Avatar for isaksson 26. isaksson Lv 1 1 pt. 13,792
  7. Avatar for spvincent 27. spvincent Lv 1 1 pt. 13,781
  8. Avatar for jausmh 28. jausmh Lv 1 1 pt. 13,776
  9. Avatar for Maerlyn138 29. Maerlyn138 Lv 1 1 pt. 13,750
  10. Avatar for Phyx 30. Phyx Lv 1 1 pt. 13,750

Comments

bkoep Staff Lv 1

Residue IE Score (max +500)
Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA, SER, THR in helices. Penalizes GLY, ALA in sheets.

Residue Count (max +1000)
Penalizes extra residues inserted beyond the starting 85, at a cost of 50 points per residue. Players may use up to 105 residues in total.

Secondary Structure (max +500)
No more than 50% of residues may form helices. Extra helices are penalized at 10 points per residue.