Placeholder image of a protein
Icon representing a puzzle

1641: Large Monomer Design

Closed since about 7 years ago

Intermediate Overall Design

Summary

Created
February 25, 2019
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 85-105 residues. The starting structure has 85 residues, but more can be added at a cost of 50 points per residue. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Gargleblasters
    1. Gargleblasters
    100 pts. 14,108
  2. Avatar for Anthropic Dreams 2. Anthropic Dreams 78 pts. 14,069
  3. Avatar for Beta Folders 3. Beta Folders 60 pts. 14,041
  4. Avatar for Void Crushers 4. Void Crushers 45 pts. 14,008
  5. Avatar for Go Science 5. Go Science 33 pts. 13,907
  6. Avatar for Contenders 6. Contenders 24 pts. 13,870
  7. Avatar for L'Alliance Francophone 7. L'Alliance Francophone 17 pts. 13,778
  8. Avatar for Marvin's bunch 8. Marvin's bunch 12 pts. 13,776
  9. Avatar for Russian team 9. Russian team 8 pts. 13,544
  10. Avatar for HMT heritage 10. HMT heritage 6 pts. 13,470
  1. Avatar for alcor29 51. alcor29 Lv 1 10 pts. 13,214
  2. Avatar for Sissue 52. Sissue Lv 1 10 pts. 13,201
  3. Avatar for Maerlyn138 53. Maerlyn138 Lv 1 9 pts. 13,126
  4. Avatar for joremen 54. joremen Lv 1 9 pts. 13,053
  5. Avatar for MicElephant 55. MicElephant Lv 1 8 pts. 13,028
  6. Avatar for cbwest 56. cbwest Lv 1 8 pts. 12,999
  7. Avatar for Arne Heessels 57. Arne Heessels Lv 1 7 pts. 12,945
  8. Avatar for jobo0502 58. jobo0502 Lv 1 7 pts. 12,934
  9. Avatar for oureion 59. oureion Lv 1 6 pts. 12,930
  10. Avatar for jermainiac 60. jermainiac Lv 1 6 pts. 12,928

Comments

bkoep Staff Lv 1

Residue IE Score (max +500)
Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA, SER, THR in helices. Penalizes GLY, ALA in sheets.

Residue Count (max +1000)
Penalizes extra residues inserted beyond the starting 85, at a cost of 50 points per residue. Players may use up to 105 residues in total.

Secondary Structure (max +500)
No more than 50% of residues may form helices. Extra helices are penalized at 10 points per residue.