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1658: Symmetric Dimer Design: 80 Residues

Closed since almost 7 years ago

Intermediate Overall Design Symmetry

Summary

Created
April 05, 2019
Expires
Max points
100
Description

This symmetric design puzzle has C2 symmetry, with two symmetric chains. There is no H-bond Network Objective in this puzzle, so the interface can be completely nonpolar (orange sidechains). No more than 50% of residues may form helices, and all loops must match one of the Ideal Loop Building Blocks found in the Blueprint tool. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for GENE 433 11. GENE 433 2 pts. 19,380
  2. Avatar for DW 2020 12. DW 2020 1 pt. 15,406
  3. Avatar for I3L GANG 13. I3L GANG 1 pt. 15,035
  4. Avatar for freefolder 14. freefolder 1 pt. 10,309
  5. Avatar for DSN @ Home 15. DSN @ Home 1 pt. 0
  6. Avatar for Hold My Beer 16. Hold My Beer 1 pt. 0
  7. Avatar for FoldIt@Poland 17. FoldIt@Poland 1 pt. 0
  8. Avatar for Deleted group 18. Deleted group pts. 0
  1. Avatar for 01010011111 91. 01010011111 Lv 1 1 pt. 11,099
  2. Avatar for lange 92. lange Lv 1 1 pt. 10,758
  3. Avatar for ALasitsa 93. ALasitsa Lv 1 1 pt. 10,343
  4. Avatar for Altercomp 94. Altercomp Lv 1 1 pt. 10,309
  5. Avatar for ti_go_Mars 95. ti_go_Mars Lv 1 1 pt. 10,214
  6. Avatar for Silvercraft 96. Silvercraft Lv 1 1 pt. 9,503
  7. Avatar for f01d 97. f01d Lv 1 1 pt. 7,077
  8. Avatar for Alpha-KetoGlutarate1301 98. Alpha-KetoGlutarate1301 Lv 1 1 pt. 1,892
  9. Avatar for manu8170 99. manu8170 Lv 1 1 pt. 1,036
  10. Avatar for SiPot2018 100. SiPot2018 Lv 1 1 pt. 0

Comments

bkoep Staff Lv 1

Core Existence: Monomer (max +2400)
Ensures that at least 24 residues are buried in the core of the monomer unit.

Core Existence: Complex (max +2600)
Ensures that at least 52 residues are buried in the core of the entire complex (including the interface between monomer units).

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

Secondary Structure (max +500)
No more than 50% of residues may form helices. Extra helices are penalized at 10 points per residue.