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1658: Symmetric Dimer Design: 80 Residues

Closed since almost 7 years ago

Intermediate Overall Design Symmetry

Summary

Created
April 05, 2019
Expires
Max points
100
Description

This symmetric design puzzle has C2 symmetry, with two symmetric chains. There is no H-bond Network Objective in this puzzle, so the interface can be completely nonpolar (orange sidechains). No more than 50% of residues may form helices, and all loops must match one of the Ideal Loop Building Blocks found in the Blueprint tool. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for GENE 433 11. GENE 433 2 pts. 19,380
  2. Avatar for DW 2020 12. DW 2020 1 pt. 15,406
  3. Avatar for I3L GANG 13. I3L GANG 1 pt. 15,035
  4. Avatar for freefolder 14. freefolder 1 pt. 10,309
  5. Avatar for DSN @ Home 15. DSN @ Home 1 pt. 0
  6. Avatar for Hold My Beer 16. Hold My Beer 1 pt. 0
  7. Avatar for FoldIt@Poland 17. FoldIt@Poland 1 pt. 0
  8. Avatar for Deleted group 18. Deleted group pts. 0
  1. Avatar for OdysseasVro 101. OdysseasVro Lv 1 1 pt. 0
  2. Avatar for agcantos 102. agcantos Lv 1 1 pt. 0
  3. Avatar for aspadistra 103. aspadistra Lv 1 1 pt. 0
  4. Avatar for IssaG 104. IssaG Lv 1 1 pt. 0
  5. Avatar for Aminal88 105. Aminal88 Lv 1 1 pt. 0
  6. Avatar for JanZizka 106. JanZizka Lv 1 1 pt. 0
  7. Avatar for Wilmerst23 107. Wilmerst23 Lv 1 1 pt. 0
  8. Avatar for ayyu 108. ayyu Lv 1 1 pt. 0
  9. Avatar for Amphimixus 109. Amphimixus Lv 1 1 pt. 0
  10. Avatar for hansvandenhof 110. hansvandenhof Lv 1 1 pt. 0

Comments

bkoep Staff Lv 1

Core Existence: Monomer (max +2400)
Ensures that at least 24 residues are buried in the core of the monomer unit.

Core Existence: Complex (max +2600)
Ensures that at least 52 residues are buried in the core of the entire complex (including the interface between monomer units).

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

Secondary Structure (max +500)
No more than 50% of residues may form helices. Extra helices are penalized at 10 points per residue.