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1658: Symmetric Dimer Design: 80 Residues

Closed since almost 7 years ago

Intermediate Overall Design Symmetry

Summary

Created
April 05, 2019
Expires
Max points
100
Description

This symmetric design puzzle has C2 symmetry, with two symmetric chains. There is no H-bond Network Objective in this puzzle, so the interface can be completely nonpolar (orange sidechains). No more than 50% of residues may form helices, and all loops must match one of the Ideal Loop Building Blocks found in the Blueprint tool. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

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  6. Avatar for Hold My Beer 16. Hold My Beer 1 pt. 0
  7. Avatar for FoldIt@Poland 17. FoldIt@Poland 1 pt. 0
  8. Avatar for Deleted group 18. Deleted group pts. 0
  1. Avatar for Arne Heessels 71. Arne Heessels Lv 1 3 pts. 16,266
  2. Avatar for lconor 72. lconor Lv 1 2 pts. 16,190
  3. Avatar for multaq 73. multaq Lv 1 2 pts. 16,052
  4. Avatar for carsonfb 74. carsonfb Lv 1 2 pts. 16,030
  5. Avatar for cbwest 75. cbwest Lv 1 2 pts. 15,703
  6. Avatar for Dhalion 76. Dhalion Lv 1 2 pts. 15,655
  7. Avatar for momadoc 77. momadoc Lv 1 2 pts. 15,618
  8. Avatar for Lyshi2018 78. Lyshi2018 Lv 1 2 pts. 15,406
  9. Avatar for ironchefnorse 79. ironchefnorse Lv 1 1 pt. 15,316
  10. Avatar for dbuske 80. dbuske Lv 1 1 pt. 15,162

Comments

bkoep Staff Lv 1

Core Existence: Monomer (max +2400)
Ensures that at least 24 residues are buried in the core of the monomer unit.

Core Existence: Complex (max +2600)
Ensures that at least 52 residues are buried in the core of the entire complex (including the interface between monomer units).

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

Secondary Structure (max +500)
No more than 50% of residues may form helices. Extra helices are penalized at 10 points per residue.